Publications by: Denise L. Doolan

Also publishes as (D.L. Doolan, Denise Doolan)

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Number of items: 111.

De Sousa, Karina P., and Doolan, Denise L. (2016) Immunomics: a 21st century approach to vaccine development for complex pathogens. Parasitology, 143 (2). pp. 236-244.

Apte, Simon H., Stephenson, Rachel J., Simerska, Pavla, Groves, Penny L., Aljohani, Salwa, Eskandari, Sharareh, Toth, Istvan, and Doolan, Denise L. (2016) Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8⁺ T-cell responses. Nanomedicine, 11 (2). pp. 137-152.

Burel, Julie G., Apte, Simon H., and Doolan, Denise L. (2016) Systems approaches towards molecular profiling of human immunity. Trends in Immunology, 37 (1). pp. 53-67.

Sotillo, Javier, Doolan, Denise, and Loukas, Alex (2016) Recent advances in proteomic applications for schistosomiasis research: potential clinical impact. Expert Review of Proteomics. pp. 1-13. (In Press)

Driguez, Patrick, Li, Yuesheng, Gaze, Soraya, Pearson, Mark S., Nakajima, Rie, Trieu, Angela, Doolan, Denise L., Felgner, Philip L., Hou, Xunya, Cardoso, Fernanda C., Jasinskas, Algis, Gobert, Geoffrey, Loukas, Alex, and McManus, Donald (2016) Antibody signatures reflect different disease pathologies in patients with schistosomiasis due to Schistosoma japonicum. Journal of Infectious Diseases, 213 (1). pp. 122-130.

Raja, Amber I., Cai, Yeping, Reiman, Jennifer M., Groves, Penny, Chakravarty, Sumana, McPhun, Virginia, Doolan, Denise L., Cockburn, Ian, Hoffman, Stephen L., Stanisic, Danielle I., and Good, Michael F. (2016) Chemically attenuated blood-stage Plasmodium yoelii parasites induce long-lived and strain-transcending protection. Infection and Immunity, 84 (8). pp. 2274-2288.

Skinner-Adams, Tina S., Sumanadasa, Subathdrage D.M., Fisher, Gillian M., Davis, Rohan A., Doolan, Denise L., and Andrews, Katherine T. (2016) Defining the targets of antiparasitic compounds. Drug Discovery Today, 21 (5). pp. 725-739.

Proietti, Carla, Zakrzewski , Martha , Watkins, Thomas S., Berger, Bernard, Hasan, Shihab, Ratnatunga, Champa N., Brion, Marie-Jo, Crompton, Peter D., Miles, John J., Doolan, Denise L., and Krause, Lutz (2016) Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) web-server. Scientific Reports, 6. pp. 1-15.

Hickey, Bradley W., Lumsden, Joanne M., Reyes, Sharina, Sedegah, Martha, Hollingdale, Michael R., Freilich, Daniel A., Luke, Thomas C., Charoenvit, Yupin, Goh, Lucy M., Berzins, Mara P., Bebris, Lolita, Sacci Jr., John B., De La Vega, Patricia, Wang, Ruobing, Ganeshan, Harini, Abot, Esteban N., Carucci, Daniel J., Doolan, Denise L., Brice, Gary T., Kumar, Anita, Aguiar, Joao, Nutman, Thomas B., Leitman, Susan F., Hoffman, Stephen L., Epstein, Judith E., and Richie, Thomas L. (2016) Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity. Malaria Journal, 15 (377). pp. 1-18.

Burel, Julie G., Apte, Simon H., McCarthy, James S., and Doolan, Denise L. (2016) Plasmodium vivax but not Plasmodium falciparum blood-stage infection in humans is associated with the expansion of a CD8+ T cell population with cytotoxic potential. PLoS Neglected Tropical Diseases, 10 (12). pp. 1-11.

Loughland, Jessica R., Minigo, Gabriela, Burel, Julie, Tipping, Peta E., Piera, Kim A., Amante, Fiona H., Engwerda, Christian Rl, Good, Michael F., Doolan, Denise L., Anstey, Nicholas M., McCarthy, James S., and Woodberry, Tonia (2016) Profoundly reduced CD1c+myeloid dendritic cell HLA-DR and CD86 expression and increased tumor necrosis factor production in experimental human blood-stage malaria infection. Infection and Immunity, 84 (5). pp. 1403-1412.

Burel, Julie G., Apte, Simon H., Groves, Penny L., Klein, Kerenaftali, McCarthy, James S., and Doolan, Denise L. (2016) Reduced plasmodium parasite burden associates with CD38(+) CD4(+) T cells displaying cytolytic potential and impaired IFN-gamma production. PLoS Pathogens, 12 (9). pp. 1-22.

Driguez, Patrick, McWilliam, Hamish E.G., Gaze, Soraya, Piedrafita, David, Pearson, Mark S., Nakajima, Rie, Duke, Mary, Trieu, Angela, Doolan, Denise L., Cardoso, Fernanda C., Jasinskas, Algis, Gobert, Geoffrey N., Felgner, Philip L., Loukas, Alex, Meeusen, Els, and McManus, Donald P. (2016) Specific humoral response of hosts with variable schistosomiasis susceptibility. Immunology and Cell Biology, 94. pp. 52-65.

Sedaghat, Bita, Stephenson, Rachel J., Giddam, Ashwini Kumar, Eskandari, Sharareh, Apte, Simon H., Pattinson, David J., Doolan, Denise L., and Toth, Istvan (2016) Synthesis of mannosylated lipopeptides with receptor targeting properties. Bioconjugate Chemistry, 27 (3). pp. 533-548.

de Oca, Marcela Montes, Kumar, Rajiv, Rivera, Fabian de Labastida, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, Shannon E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Boyle, Glen M., Price, Ric N., Anstey, Nicholas M., Loughland, Jessica R., Burel, Julie, Doolan, Denise, Haque, Ashraful, McCarthy, James S., and Engwerda, Christian R. (2016) Type I interferons regulate immune responses in humans with blood-stage Plasmodium falciparum infection. Cell Reports, 17 (2). pp. 399-412.

Davies, D. Huw, Duffy, Patrick, Bodmer, Jean-Luc, Felgner, Philip L., and Doolan, Denise L. (2015) Large screen approaches to identify novel malaria vaccine candidates. Vaccine, 33 (52). pp. 7496-7505.

Burel, Julie G., Apte, Simon H., and Doolan, Denise L. (2015) Development of a cytokine-secreting-based assay for the identification, sorting and transcriptomic analysis of polyfunctional human T cells. European Cytokine Network, 26 (4). pp. 67-72.

Pearson, Mark S., Becker, Luke, Driguez, Patrick, Young, Neil D., Gaze Jangola, Soraya, Mendes, Tiago, Li, Xiao-Hong, Doolan, Denise L., Midzi, Nicholas, Mduluza, Takafira, McManus, Donald P., Wilson, R. Alan, Bethony, Jeffrey M., Nausch, Norman, Mutapi, Francisca, Felgner, Philip L., and Loukas, Alex (2015) Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates. Frontiers in Immunology, 6. pp. 1-13.

Tribolet, Leon, Cantacessi, Cinzia, Pickering, Darren, Navarro, Severine, Doolan, Denise, Trieu, Angela, Fei, Huang, Chao, Yang, Hofmann, Andreas, Gasser, Robin, Giacomin, Paul, and Loukas, Alex (2015) Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling. Journal of Infectious Diseases, 211 (3). pp. 416-425.

Proietti, Carla, and Doolan, Denise L. (2015) The case for a rational genome-based vaccine against malaria. Frontiers in Microbiology, 5. pp. 1-19.

Eskandari, Sharareh, Stephenson, Rachel J., Fuaad, Abdullah Ahmad, Apte, Simon H., Doolan, Denise L., and Toth, Istvan (2015) Synthesis and characterisation of self-assembled and self-adjuvanting asymmetric multi-epitope lipopeptides of ovalbumin. Chemistry: a European journal, 21 (3). pp. 1251-1261.

Driguez, Patrick, Doolan, Denise L., Molina, Douglas M., Loukas, Alex, Trieu, Angela, Felgner, Phil L., and McManus, Donald P. (2015) Protein microarrays for parasite antigen discovery. In: Peacock, Christopher, (ed.) Parasite Genomics Protocols. Methods in Molecular Biology (1201). Springer, New York, NY, USA, pp. 221-233.

Doolan, Denise L., Apte, Simon H., and Proietti, Carla (2014) Genome-based vaccine design: the promise for malaria and other infectious diseases. International Journal for Parasitology, 44 (12). pp. 901-913.

Gaze, Soraya, Driguez, Patrick, Pearson, Mark S., Mendes, Tiago, Doolan, Denise L., Trieu, Angela, McManus, Donald P., Gobert, Geoffrey N., Periago, Maria Victoria, Correa Oliveira, Rodrigo, Cardoso, Fernanda C., Oliveira, Guilherme, Nakajima, Rie, Jasinskas, Al, Hung, Chris, Liang, Li, Pablo, Jozelyn, Bethony, Jeffrey M., Felgner, Philip L., and Loukas, Alex (2014) An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas. PLoS Pathogens, 10 (3). pp. 1-16.

Schussek, Sophie, Trieu, Angela, and Doolan, Denise L. (2014) Genome- and proteome-wide screening strategies for antigen discovery and immunogen design. Biotechnology Advances, 32 (2). pp. 403-414.

Schussek, Sophie, Groves, Penny L., Apte, Simon H., and Doolan, Denise L. (2013) Highly sensitive quantitative real-time PCR for the detection of Plasmodium liver-stage parasite burden following low-dose sporozoite challenge. PLoS ONE, 8 (10). pp. 1-10.

Schussek, Sophie, Trieu, Angela, Apte, Simon H., Sidney, John, Sette, Alessandro, and Doolan, Denise L. (2013) Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model. Infection and Immunity, 81 (10). pp. 3586-3599.

Apte, Simon H., Redmond, Andrew M., Groves, Penny L., Schussek, Sophie, Pattinson, David J., and Doolan, Denise L. (2013) Subcutaneous cholera toxin exposure induces potent CD103⁺ dermal dendritic cell activation and migration. European Journal of Immunology, 43 (10). pp. 2707-2717.

Tarigo, Jaime L., Scholl, Elizabeth H., Bird, David McK., Brown, Corrie C., Cohn, Leah A., Dean, Gregg A., Levy, Michael G., Doolan, Denise L., Trieu, Angela, Nordone, Shila K., Felgner, Philip L., Vigil, Adam, and Birkenheuer, Adam J. (2013) A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics. PLoS ONE, 8 (8). pp. 1-9.

Sedegah, Martha, Kim, Yohan, Ganeshan, Harini, Huang, Jun, Belmonte, Maria, Abot, Esteban, Banania, Jo Glenna, Farooq, Fouzia, McGrath, Shannon, Peters, Bjoern, Sette, Alessandro, Soisson, Lorraine, Diggs, Carter, Doolan, Denise, Tamminga, Cindy, Villasante, Eileen, Hollingdale, Michael R., and Richie, Thomas L. (2013) Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP). Malaria Journal, 12. pp. 1-17.

Chuang, Ilin, Sedegah, Martha, Cicatelli, Susan, Spring, Michele, Polhemus, Mark, Tamminga, Cindy, Patterson, Noelle, Guerrero, Melanie, Bennett, Jason W., McGrath, Shannon, Ganeshan, Harini, Belmonte, Maria, Farooq, Fouzia, Abot, Esteban, Banania, Jo Glenna, Huang, Jun, Newcomer, Rhonda, Rein, Lisa, Litilit, Dianne, Richie, Nancy O., Wood, Chloe, Murphy, Jittawadee, Sauerwein, Robert, Hermsen, Cornelus C., McCoy, Andrea J., Kamau, Edwin, Cummings, James, Komisar, Jack, Sutamihardja, Awalludin, Shi, Meng, Epstein, Judith E., Maiolatesi, Santina, Tosh, Donna, Limbach, Keith, Angov, Evelina, Bergmann-Leitner, Elke, Bruder, Joseph T., Doolan, Denise L., King, C. Richter, Carucci, Daniel, Dutta, Sheetij, Soisson, Lorraine, Diggs, Carter, Hollingdale, Michael R., Ockenhouse, Christian F., and Richie, Thomas L. (2013) DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity. PLoS ONE, 8 (2). pp. 1-15.

Doolan, Denise (2012) Editorial. International Journal for Parasitology: Parasites and Wildlife, 1 (1). p. 1.

Richie, Thomas L., Charoenvit, Yupin, Wang, Ruobing, Epstein, Judith E., Hedstrom, Richard C., Kumar, Sanjai, Luke, Thomas C., Freilich, Daniel A., Aguiar, Joao C., Sacci, Jr., John B., Sedegah, Martha, Nosek, Jr., Ronald A., De La Vega, Patricia, Berzins, Mara P., Majam, Victoria F., Abot, Esteban N., Ganeshan, Harini, Richie, Nancy O., Banania, Jo Glenna, Baraceros, Maria Fe B., Geter, Tanya, Mere, Robin, Bebris, Lolita, Limbach, Keith, Hickey, Bradley W., Lanar, David E., Ng, Jennifer, Shi, Meng, Hobart, Peter M., Norman, Jon A., Soisson, Lorraine A., Hollingdale, Michael R., Rogers, William O., Doolan, Denise L., and Hoffman, Stephen L. (2012) Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA. Human Vaccines & Immunotherapeutics, 8 (11). pp. 1564-1584.

Apte, Simon h., Groves, Penny L., Skwarczynski, Mariusz, Fujita, Yoshio, Chang, Chenghung, Toth, Istvan, and Doolan, Denise L. (2012) Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model. PLoS ONE, 7 (8). pp. 1-11.

Bruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L., and Doolan, Denise L. (2012) Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. PLoS ONE, 7 (4). pp. 1-13.

Quelhas, Diana, Puyol, Laura, Quintó, Llorenç, Nhampossa, Tacilta, Serra-Casas, Elisa, Macete, Eusébio, Aide, Pedro, Sanz, Sergi, Aponte, John J., Doolan, Denise L., Alonso, Pedro L., Menéndez, Clara, and Dobaño, Carlota (2012) Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children. BMC Immunology, 13 (5). pp. 1-18.

Doolan, Denise L., and Apte, Simon H. (2012) Addressing the bottleneck at clinical testing of candidate malaria vaccines. Pathogens and Global Health, 106 (6). pp. 321-322.

Loukas, Alex, Gaze, Soraya, Pearson, Mark, Doolan, Denise, Felgner, Philip, Diemert, David, McManus, Donald P., Driguez, Patrick, and Bethony, Jeffrey (2012) Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates. In: Caffrey, Conor R., (ed.) Parasitic Helminths: targets, screens, drugs and vaccines. Drug Discovery in Infectious Diseases . Wiley-Blackwell, Weinheim, Germany, pp. 421-433.

Guinovart, Caterina, Dobaño, Carlota, Bassat, Quique, Nhabomba, Augusto, Quintó, Llorenc, Manaca, Maria Nélia, Aguilar, Ruth, Rodríguez, Mauricio H., Barbosa, Arnoldo, Aponte, John J., Mayor, Alfredo G., Renom, Monste, Moraleda, Cinta, Roberts, David J., Schwarzer, Evelin, Le Souëf, Peter N., Schofield, Louis, Chitnis, Chetan E., Doolan, Denise L., and Alonso, Pedro L. (2012) The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial. PLoS ONE, 7 (3). pp. 1-11.

Doolan, Denise L., and Spithill, Terry (2011) Editorial. International Journal for Parasitology: Drugs and Drugs Resistance, 1 (1). p. 1.

Cardoso, Fernanda C., Roddick, Joanne S., Groves, Penny, and Doolan, Denise L. (2011) Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale. PLoS ONE, 6 (11). pp. 1-14.

Sedegah, Martha, Tamminga, Cindy, McGrath, Shannon, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J., Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Manohar, Nalini, Richie, Nancy O., Wood, Chloe, Long, Carole A., Regis, David, Williams, Francis T., Shi, Meng, Chuang, Ilin, Spring, Michele, Epstein, Judith E., Mendoza-Silveiras, Jose, Limbach, Keith, Patterson, Noelle B., Bruder, Joseph T., Doolan, Denise L., King, C. Richter, Soisson, Lorraine, Diggs, Carter, Carucci, Daniel, Dutta, Sheetij, Hollingdale, Michael R., Ockenhouse, Christian F., and Richie, Thomas L. (2011) Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults. PLoS ONE, 6 (10). pp. 1-22.

Tamminga, Cindy, Sedegah, Martha, Regis, David, Chuang, Ilin, Epstein, Judith E., Spring, Michele, Mendoza-Silveiras, Jose, McGrath, Shannon, Maiolatesi, Santina, Reyes, Sharina, Steinbeiss, Victoria, Fedders, Charlotte, Smith, Kathryn, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J., Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Murphy, Jittawadee, Komisar, Jack, Williams, Jackie, Shi, Meng, Brambilla, Donald, Manohar, Nalini, Richie, Nancy O., Wood, Chloe, Limbach, Keith, Patterson, Noelle B., Bruder, Joseph T., Doolan, Denise L., King, C. Richter, Diggs, Carter, Soisson, Lorraine, Carucci, Daniel, Levine, Gail, Dutta, Sheetij, Hollingdale, Michael R., Ockenhouse, Christian F., and Richie, Thomas L. (2011) Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS ONE, 6 (10). pp. 1-20.

Apte, Simon H., Groves, Penny L., Roddick, Joanne S., da Hora, Vanusa P., and Doolan, Denise L. (2011) High-throughput multi-parameter flow-cytometric analysis from micro-quantities of Plasmodium-infected blood. International Journal for Parasitology, 41 (12). pp. 1285-1294.

Loukas, Alex, Gaze, Soraya, Mulvenna, Jason, Gasser, Robin, Brindley, Paul, Doolan, Denise, Bethony, Jeffrey, Jones, Malcolm, Gobert, Geoffrey, Drigues, Patrick, McManus, Donald, and Hotez, Peter (2011) Vaccinomics for the major blood feeding helminths of humans. OMICS: a Journal of Integrative Biology, 15 (11). pp. 567-577.

Barry, Alyssa E., Trieu, Angela, Fowkes, Freya J.I, Pablo, Jozelyn, Kalantari-Dehaghi, Mina, Jasinskas, Algis, Tan, Xiaolin, Kayala, Matthew A., Tavul, Livingstone, Siba, Peter M., Day, Karen P., Baldi, Pierre, Felgner, Philip L., and Doolan, Denise L. (2011) The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area. Molecular and Cellular Proteomics, 10 (11). pp. 1-13.

Campo, Joseph J., Whitman, Timothy J., Freilich, Daniel, Burgess, Timothy H., Martin, Gregory J., and Doolan, Denise L. (2011) Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. PLoS ONE, 6 (7). pp. 1-6.

Dodoo, Daniel, Hollingdale, Michael R., Anum, Dorothy, Koram, Kwadwo A., Gyan, Ben, Akanmori, Bartholomew D., Ocran, Josephine, Adu-Amankwah, Susan, Geneshan, Harini, Abot, Esteban, Legano, Jennylyn, Banania, Glenna, Sayo, Renato, Brambilla, Donald, Kumar, Sanjai, Doolan, Denise L., Rogers, William O., Epstein, Judith, Richie, Thomas L., and Sedegah, Martha (2011) Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults. Malaria Journal, 10 (168). pp. 1-18.

Douradinha, Bruno, and Doolan, Denise L. (2011) Harnessing immune responses against Plasmodium for rational vaccine design. Trends in Parasitology, 27 (6). pp. 274-283.

Trieu, Angela, Kayala, Matthew A., Burk, Chad, Molina, Douglas M., Freilich, Daniel A., Richie, Thomas L., Baldi, Pierre, Felgner, Philip L., and Doolan, Denise L. (2011) Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Molecular and Cellular Proteomics, 10 (9). pp. 1-15.

da Hora, Vanusa P., Conceição, Fabricio R., Dellagostin, Odir A., and Doolan, Denise L. (2011) Non-toxic derivatives of LT as potent adjuvants. Vaccine, 29 (8). pp. 1538-1544.

Doolan, Denise L. (2011) Plasmodium immunomics. International Journal for Parasitology, 41 (1). pp. 3-20.

Good, Michael F., and Doolan, Denise L. (2010) Malaria vaccine design: immunological considerations. Immunity, 33 (4). pp. 555-566.

Sedegah, Martha, Kim, Yohan, Peters, Bjoern, McGrath, Shannon, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna, Belmonte, Maria, Sayo, Renato, Farooq, Fouzia, Doolan, Denise L., Regis, David, Tamminga, Cindy, Chuang, Ilin, Bruder, Joseph T., King, C. Richter, Ockenhouse, Christian F., Faber, Bart, Remarque, Edmond, Hollingdale, Michael R., Richie, Thomas L., and Sette, Alessandro (2010) Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malaria Journal, 9 (241). pp. 1-16.

Redmond, A.M., and Doolan, D.L. (2010) The Australasian contribution to malaria vaccine development. Parasite Immunology, 32 (8). pp. 607-622.

Apte, Simon H., Groves, Penny, Olver, Stuart, Baz, Adriana, Doolan, Denise L., Kelso, Anne, and Kienzle, Norbert (2010) IFN-γ inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response. Journal of Immunology, 185 (2). pp. 998-1004.

Bruder, Joseph T., Stefaniak, Maureen E., Patterson, Noelle B., Chen, Ping, Konovalova, Svetlana, Limbach, Keith, Campo, Joseph J., Ettyreddy, Damodar, Li, Sheng, Dubovsky, Filip, Richie, Thomas L., King, C. Richter, Long, Carole A., and Doolan, Denise (2010) Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth. Vaccine, 28 (18). pp. 3201-3210.

Crompton, Peter D., Kayala, Matthew A., Traore, Boubacar, Kayentao, Kassoum, Ongoiba, Aissata, Weiss, Greta E., Molina, Douglas M., Burk, Chad R., Waisberg, Michael, Jasinskas, Algis, Tan, Xiaolin, Doumbo, Safiatou, Doumtabe, Didier, Kone, Younoussou, Narum, David L., Liang, Xiaowu, Doumbo, Ogobara K., Miller, Louis H., Doolan, Denise L., Baldi, Pierre, Felgner, Philip L., and Pierce, Susan K. (2010) A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray. Proceedings of the National Academy of Sciences, 107 (15). pp. 6958-6963.

Sedegah, Martha, Rogers, William O., Belmonte, Maria, Belmonte, Arnel, Banania, Glenna, Patterson, Noelle B., Rusalov, Denis, Ferrari, Marilyn, Richie, Thomas L., and Doolan, Denise L. (2010) Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses. Vaccine, 28 (17). pp. 3055-3065.

Driguez, Patrick, Doolan, Denise L., Loukas, Alex, Felgner, Philip L., and McManus, Donald P. (2010) Schistosomiasis vaccine discovery using immunomics. Parasites & Vectors, 3 (1). pp. 1-5.

Jiang, George, Shi, Meng, Conteh, Solomon, Richie, Nancy, Banania, Glenna, Geneshan, Harini, Valencia, Anais, Singh, Priti, Aguiar, Joao, Limbach, Keith, Kamrud, Kurt I., Rayner, Jonathan, Smith, Jonathan, Bruder, Joseph T., King, C. Richter, Tsuboi, Takafumi, Takeo, Satoru, Endo, Yaeta, Doolan, Denise L., Richie, Thomas L., and Weiss, Walter R. (2009) Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies. PLoS ONE, 4 (8). pp. 1-12.

Woodberry, Tonia, Pinzon-Charry, Alberto, Piera, Kim A., Panpisutchai, Yawalak, Engwerda, Christian R., Doolan, Denise L., Salwati, Ervi, Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Good, Michael F., and Anstey, Nicholas M. (2009) Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria. Malaria Journal, 8 (122). pp. 1-10.

Dobaño, Carlota, Sedegah, Martha, Rogers, William O., Kumar, Sanjai, Zheng, Hong, Hoffman, Stephen L., and Doolan, Denise L. (2009) Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity. Experimental Parasitology, 122 (2). pp. 112-123.

Vaughan, K., Blythe, M., Greenbaum, J., Zhang, Q., Peters, B., Doolan, D.L., and Sette, A. (2009) Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues. Parasite Immunology, 31 (2). pp. 78-97.

Doolan, Denise L., Dobaño, Carlota, and Baird, J. Kevin (2009) Acquired immunity to malaria. Clinical Microbiology Reviews, 22 (1). pp. 13-36.

Doolan, Denise L., Mu, Yunxiang, Unal, Berkay, Sundaresh, Suman, Hirst, Siddiqua, Valdez, Conrad, Randall, Arlo, Molina, Douglas, Liang, Xiaowu, Freilich, Daniel A., Oloo, J. Aggrey, Blair, Peter L., Aguiar, Joao C., Baldi, Pierre, Davies, D. Huw, and Felgner, Philip L. (2008) Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics, 8 (22). pp. 4680-4694.

Regis, David P., Dobaño, Carlota, Quiñones-Olson, Paola, Liang, Xiaowu, Graber, Norma L., Stefaniak, Maureen E., Campo, Joseph J., Carucci, Daniel J., Roth, David A., He, Huaping, Felgner, Philip L., and Doolan, Denise L. (2008) Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity. Molecular and Biochemical Parasitology, 158 (1). pp. 32-45.

Jiang, George, Charoenvit, Yupin, Moreno, Alberto, Baraceros, Maria F., Banania, Glenna, Richie, Nancy, Abot, Steve, Ganeshan, Harini, Fallarme, Victoria, Patterson, Noelle B., Geall, Andrew, Weiss, Walter R., Strobert, Elizabeth, Caro-Aquilar, Ivette, Lanar, David E., Saul, Allan, Martin, Laura B., Gowda, Kalpana, Morrissette, Craig R., Kaslow, David C., Carucci, Daniel J., Galinski, Mary R., and Doolan, Denise L. (2007) Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malaria Journal, 6 (135). pp. 1-17.

Brice, Gary T., Dobaño, Carlota, Sedegah, Martha, Stefaniak, Maureen, Graber, Norma L., Campo, Joseph J., Carucci, Daniel J., and Doolan, Denise L. (2007) Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes and Infection, 9 (12-13). pp. 1439-1446.

Dobaño, Carlota, Widera, Georg, Rabussay, Dietmar, and Doolan, Denise L. (2007) Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation. Vaccine, 25 (36). pp. 6635-6645.

Dobaño, Carlota, Rogers, William O., Gowda, Kalpana, and Doolan, Denise L. (2007) Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines. Immunology Letters, 111 (2). pp. 92-102.

Dobaño, C., and Doolan, D.L. (2007) Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17 kDa. Molecular Immunology, 44 (11). pp. 3037-3048.

Li, Shengqiang, Locke, Emily, Bruder, Joseph, Clarke, David, Doolan, Denise L., Havenga, Menzo J.E., Hill, Adrian V.S., Liljestrom, Peter, Monath, Thomas P., Naim, Hussein Y., Ockenhouse, Christian, Tang, De-chu C., Van Kampen, Kent R., Viret, Jean-Francois, Zavala, Fidel, and Dubovsky, Filip (2007) Viral vectors for malaria vaccine development. Vaccine, 25 (14). pp. 2567-2574.

Dobaño, C., McTague, A., Sette, A., Hoffman, S.L., Rogers, W.O., and Doolan, D.L. (2007) Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria. Molecular Immunology, 44 (9). pp. 2235-2248.

Doolan, Denise L., Freilich, Daniel A., Brice, Gary T., Burgess, Timothy H., Berzins, Mara P., Bull, Robert L., Graber, Norma L., Dabbs, Jason L., Shatney, Lori L., Blazes, David L., Bebris, Lolita M., Malone, Maria F., Eisold, John F., Mateczun, Alfred J., and Martin, Gregory J. (2007) The US Capitol bioterrorism anthrax exposures: clinical epidemiological and immunological characteristics. Journal of Infectious Diseases, 195 (2). pp. 174-184.

Chen, Ping, Konovalova, Svetlana, Limbach, Keith, Stefaniak, Maureen E., Patterson, Noelle B., Campo, Joseph J., Li, Sheng, King, Richter, Doolan, Denise L., and Bruder, Joseph T. (2006) Construction and characterization of adenovirus vectors expressing optimized blood stage antigens of Plasmodium falciparum. Molecular Therapy, 13 (S1). S8-S9.

Sedegah, Martha, Rogers, William O., Belmonte, Arnel, Belmonte, Maria, Banania, Glenna, Patterson, Noelle, Ferrari, Marilyn, Kaslow, David C., Carucci, Daniel J., Richie, Thomas L., and Doolan, Denise L. (2006) Vaxfectin™ enhances immunogenicity and protective efficacy of P. yoelii circumsporozoite DNA vaccines. Vaccine, 24 (11). pp. 1921-1927.

Sundaresh, Suman, Doolan, Denise L., Hirst, Siddiqua, Mu, Yunxiang, Unal, Berkay, Davies, D. Huw, Felgner, Philip L., and Baldi, Pierre (2006) Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques. Bioinformatics, 22 (14). pp. 1760-1766.

Doolan, D.L., and Martinez-Alier, N. (2006) Immune response to pre-erythrocytic stages of malaria parasites. Current Molecular Medicine, 6 (2). pp. 169-185.

Charoenvit, Yupin, Brice, Gary T., Bacon, David, Majam, Victoria, Williams, Jackie, Abot, Esteban, Ganeshan, Harini, Sedegah, Martha, Doolan, Denise L., Carucci, Daniel J., and Zimmerman, Daniel H. (2004) A small peptide (CEL-1000) derived from the β-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner. Antimicrobial Agents and Chemotherapy, 48 (7). pp. 2455-2463.

Doolan, Denise L., Southwood, Scott, Freilich, Daniel A., Sidney, John, Graber, Norma L., Shatney, Lori, Bebris, Lolita, Florens, Laurence, Dobano, Carlota, Witney, Adam A., Appella, Ettore, Hoffman, Stephen L., Yates, John R., Carucci, Daniel J., and Sette, Alessandro (2003) Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proceedings of the National Academy of Sciences of the United States of America, 100 (17). pp. 9952-9957.

Doolan, D.L., Aguiar, J.C., Weiss, W.R., Sette, A., Felgner, P.L., Regis, D.P., Quinones-Casas, P., Yates, J.R., Blair, P.L., Richie, T.L., Hoffman, S.L., and Carucci, D.J. (2003) Utilization of genomic sequence information to develop malaria vaccines. Journal of Experimental Biology, 206. pp. 3789-3802.

Sedegah, Martha, Brice, Gary T., Rogers, William O., Doolan, Denise L., Charoenvit, Yupin, Jones, Trevor R., Majam, Victoria F., Belmonte, Arnel, Lu, Minh, Belmonte, Maria, Carucci, Daniel J., and Hoffman, Stephen L. (2002) Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8⁺-T-cell populations. Infection and Immunity, 70 (7). pp. 3493-3499.

Doolan, Denise L. (2002) Assessing antigen-specific CD8+ CTL responses in humans. In: Doolan, Denise L., (ed.) Malaria Methods and Protocols. Methods in Molecular Medicine, 72 . Humana Press, New Jersey, NY, USA, pp. 445-456.

Hedstrom, Richard C., and Doolan, Denise L. (2002) DNA vaccination. In: Doolan, Denise L., (ed.) Malaria Methods and Protocols. Methods in Molecular Medicine, 72 . Humana Press, New Jersey, NY, USA, pp. 347-360.

Witney, Adam A., Doolan, Denise L., Anthony, Robert M., Weiss, Walter R., Hoffman, Stephen L., and Carucci, Daniel J. (2001) Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy. Molecular and Biochemical Parasitology, 118 (2). pp. 233-245.

Doolan, Denise L., Coppel, Ross L., and Waters, Andrew P. (2001) Foreword: MBP thematic issue on genomics. Molecular and Biochemical Parasitology, 118 (2). pp. 127-128.

Brice, Gary T., Graber, Norma L., Hoffman, Stephen L., and Doolan, Denise L. (2001) Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cells. Journal of Immunological Methods, 257 (1-2). pp. 55-69.

Wang, Ruobing, Epstein, Judith, Baraceros, Fe Maria, Gorak, Edward J., Charoenvit, Yupin, Carucci, Daniel J., Hedstrom, Richard C., Rahardjo, Nancy, Gay, Tanya, Hobart, Peter, Stout, Rick, Jones, Trevor R., Richie, Thomas L., Parker, Suezanne E., Doolan, Denise L., Norman, Jon, and Hoffman, Stephen L. (2001) Induction of CD4⁺ T cell-dependent CD8⁺ type 1 responses in humans by a malaria DNA vaccine. Proceedings of the National Academy of Sciences of the United States of America, 98 (19). pp. 10817-10822.

Doolan, Denise L., and Hoffman, Stephen L. (2001) DNA-based vaccines against malaria: status and promise of the Multi-Stage Malaria DNA Vaccine Operation. International Journal for Parasitology, 31 (8). pp. 753-762.

Gramzinski, Robert A., Doolan, Denise L., Sedegah, Martha, Davis, Heather L., Krieg, Arthur M., and Hoffman, Stephen L. (2001) Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infection and Immunity, 69 (3). pp. 1643-1649.

Hoffman, Stephen L., and Doolan, Denise L. (2000) Malaria vaccines-targeting infected hepatocytes. Nature Medicine, 6 (11). pp. 1218-1219.

Ravichandran, Manickam, Doolan, Denise L., Cox-Singh, Janet, Hoffman, Stephen L., and Singh, Balbir (2000) HLA degenerate T-cell epitopes from Plasmodium falciparum liver stage-specific antigen 1 (LSA-1) are highly conserved in isolates from geographically distinct areas. Parasite Immunology, 22 (9). pp. 469-473.

Le, Thong P., Coonan, Kevin M., Hedstrom, Richard C., Charoenvit, Yupin, Sedegah, Martha, Epstein, Judith E., Kumar, Sanjai, Wang, Ruobing, Doolan, Denise L., Maguire, Jason D., Parker, Suezanne E., Hobart, Peter, Norman, Jon, and Hoffman, Stephen L. (2000) Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine, 18 (18). pp. 1893-1901.

Good, Michael F., and Doolan, Denise L. (1999) Immune effector mechanisms in malaria. Current Opinion in Immunology, 11 (4). pp. 412-419.

Wang, Ruobing, Doolan, Denise L., Le, Thong P., Hedstrom, Richard C., Coonan, Kevin M., Charoenvit, Yupin, Jones, Trevor R., Hobart, Peter, Margalith, Michal, Ng, Jennifer, Weiss, Walter R., Sedegah, Martha, de Taisne, Charles, Norman, Jon A., and Hoffman, Stephen L. (1998) Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science, 282 (5388). pp. 476-480.

Doolan, Denise L., Hoffman, Stephen L., Southwood, Scott, Wentworth, Peggy A., Sidney, John, Chesnut, Robert W., Keogh, Elissa, Appella, Ettore, Nutman, Thomas B., Lal, Altaf A., Gordon, Daniel M., Oloo, Aggrey, and Sette, Alessandro (1997) Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity, 7 (1). pp. 97-112.

Gramzinski, Robert A., Maris, Dorina C., Doolan, Denise, Charoenvit, Yupin, Obaldia, Nicanor, Rossan, Richard, Sedegah, Martha, Wang, Ruobing, Hobart, Peter, Margalith, Michal, and Hoffman, Stephen (1997) Malaria DNA vaccines in Aotus monkeys. Vaccine, 15 (8). pp. 913-915.

Hoffman, Stephen L., Doolan, Denise L., Sedegah, Martha, Aguiar, Joao C., Wang, Ruobing, Malik, Anita, Gramzinski, Robert A., Weiss, Walter R., Hobart, Peter, Norman, Jon A., Margalith, Michal, and Hedstrom, Richard C. (1997) Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use. Vaccine, 15 (8). pp. 842-845.

Hedstrom, Richard C., Doolan, Denise L., Wang, Ruobing, Gardner, Malcolm J., Kumar, Anita, Sedegah, Martha, Gramzinski, Robert A., Sacci, John B., Charoenvit, Yupin, Weiss, Walter R., Margalith, Michal, Norman, Jon A., Hobart, Peter, and Hoffman, Stephen L. (1997) The development of a multivalent DNA vaccine for malaria. Springer Seminars in Immunopathology, 19 (2). pp. 147-159.

Doolan, D.L., and Hoffman, S.L. (1997) Multi-gene vaccination against malaria: a multistage, multi-immune response approach. Parasitology Today, 13 (5). pp. 171-178.

Hoffman, Stephen L., Doolan, Denise L., Sedegah, Martha, Wang, Ruobing, Scheller, Libia F., Kumar, Anita, Weiss, Walter R., Le, Thong P., Klinman, Dennis M., Hobart, Peter, Norman, Jon, and Hedstrom, Richard C. (1997) Toward clinical trials of DNA vaccines against malaria. Immunology and Cell Biology, 75. pp. 376-381.

Gardner, Malcolm J., Doolan, Denise L., Hedstrom, Richard C., Wang, Ruobing, Sedegah, Martha, Gramzinski, Robert A., Aguiar, Joao C., Wang, Helen, Margalith, Michal, Hobart, Peter, and Hoffman, Stephen L. (1996) DNA vaccines against malaria: immunogenicity and protection in a rodent model. Journal of Pharmaceutical Sciences, 85 (12). pp. 1294-1300.

Doolan, Denise L., Sedegah, Martha, Hedstrom, Richard C., Hobart, Peter, Charoenvit, Yupin, and Hoffman, Stephen L. (1996) Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon γ-, and nitric oxide-dependent immunity. The Journal of Experimental Medicine, 183 (4). pp. 1739-1746.

Doolan, Denise L., Wizel, Benjamin, and Hoffman, Stephen L. (1996) Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs. Immunologic Research, 15 (4). pp. 280-305.

Hoffman, S.L., Doolan, D.L., Sedegah, M., Gramzinski, R., Wang, H., Gowda, K., Hobart, P., Margalith, M., Norman, J., and Hedstrom, R. (1995) Nucleic acid malaria vaccines. Annals of the New York Academy of Sciences, 772. pp. 88-94.

Argaet, Victor P., Schmidt, Christopher W., Burrows, Scott R., Silins, Sharon L., Kurilla, Mike G., Doolan, Denise L., Suhrbier, Andreas, Moss, Denis J., Kieff, Elliot, Sculley, Tom B., and Misko, Ihor S. (1994) Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. The Journal of Experimental Medicine, 180 (6). pp. 2335-2340.

Doolan, Denise L., Beck, Hans-Peter, and Good, Michael F. (1994) Evidence for limited activation of distinct CD4⁺ T cell subsets in response to the Plasmodium falciparum circumsporozoite protein in Papua New Guinea. Parasite Immunology, 16 (3). pp. 129-136.

Doolan, Denise L., Khamboonruang, Chirasak, Beck, Hans-Peter, Houghten, Richard A., and Good, Michael F. (1993) Cytotoxic T lymphocyte (CTL) low-responsiveness to the Plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: analysis of human CTL response to most known variants. International Immunology, 5 (1). pp. 37-46.

Walker, Peter J., Byrne, Keren A., Cybinski, D. H., Doolan, Denise, and Wang, Yonghong (1991) Proteins of bovine ephemeral fever virus. Journal of General Virology, 72. pp. 67-74.

Doolan, Denise L., Houghten, Richard A., and Good, Michael F. (1991) Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein. International Immunology, 3 (6). pp. 511-516.

This list was generated on Sat Mar 25 02:26:12 2017 AEST.