Immune response to pre-erythrocytic stages of malaria parasites

Doolan, D.L., and Martinez-Alier, N. (2006) Immune response to pre-erythrocytic stages of malaria parasites. Current Molecular Medicine, 6 (2). pp. 169-185.

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Abstract

Immunization with radiation-attenuated Plasmodium spp. sporozoites induces sterile protective immunity against parasite challenge. This immunity is targeted primarily against the intrahepatic parasite and appears to be sustained long term even in the absence of sporozoite exposure. It is mediated by multifactorial mechanisms, including T cells directed against parasite antigens expressed in the liver stage of the parasite life cycle and antibodies directed against sporozoite surface proteins. In rodent models, CD8+ T cells have been implicated as the principal effector cells, and IFN-γ as a critical effector molecule. IL-4 secreting CD4+ T cells are required for induction of the CD8+ T cell responses, and Th1 CD4+ T cells provide help for optimal CD8+ T cell effector activity. Components of the innate immune system, including gamma-delta T cells, natural killer cells and natural killer T cells, also play a role. The precise nature of pre-erythrocytic stage immunity in humans, including the contribution of these immune responses to the age-dependent immunity naturally acquired by residents of malaria endemic areas, is still poorly defined. The importance of immune effector targets at the pre-erythrocytic stage of the parasite life cycle is highlighted by the fact that infection-blocking immunity in humans rarely, if ever, occurs under natural conditions. Herein, we review our current understanding of the molecular and cellular aspects of preerythrocytic stage immunity.

Item ID: 42750
Item Type: Article (Refereed Research - C1)
Keywords: pre-erythrocytic, T cells, cytokines, immunity, protection, regulation, antigen presentation, antigen persistence
ISSN: 1875-5666
Funders: US Army Medical Research Material Command (US Army RMC)
Projects and Grants: US Army MRC A0309
Date Deposited: 30 Jan 2017 04:19
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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