Toward clinical trials of DNA vaccines against malaria

Hoffman, Stephen L., Doolan, Denise L., Sedegah, Martha, Wang, Ruobing, Scheller, Libia F., Kumar, Anita, Weiss, Walter R., Le, Thong P., Klinman, Dennis M., Hobart, Peter, Norman, Jon, and Hedstrom, Richard C. (1997) Toward clinical trials of DNA vaccines against malaria. Immunology and Cell Biology, 75. pp. 376-381.

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In mid 1997 the first malaria DNA vaccine will enter clinical trials. This single gene DNA vaccine encoding the Plasmodium falciparum circumsporozoite protein (PfCSP) will be studied for safety and immunogenicity. If these criteria are met, a multi-gene DNA vaccine designed to induce protective CDS8+ T cell responses against P. falciparum infected hepatocytes will be subsequently assessed for safety, immunogenicity and capacity to protect immunized volunteers against experimental challenge with P. falciparum sporozoites. Our perspectives on malaria vaccine development in general,1 and on a multi-gene DNA vaccine in particular,2 have been recently reviewed. Herein, we review the rationale and experimental foundation for the anticipated P. falciparum DNA vaccine trials.

Item ID: 42778
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: DNA vaccine, malaria, Plasmodium, protective immunity
Funders: Naval Medical Research and Development Command (NMRDC)
Projects and Grants: NMRDC Work Unit No. 62787A00101EVX, NMRDC Work Unit No. 61102A.00101-BFX, NMRDC Work Unit No. 62787A00101EFX
Date Deposited: 15 Sep 2016 01:23
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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