IgM in human immunity to Plasmodium falciparum malaria

Boyle, M.J., Chan, J.A., Handayuni, I., Reiling, L., Feng, G., Hilton, A., Kurtovic, L., Oyong, D., Piera, K.A., Barber, B.E., William, T., Eisen, D.P., Minigo, G., Langer, C., Drew, D.R., Rivera, F. de Labastida, Amante, F.H., Williams, T.N., Kinyanjui, S., Marsh, K., Doolan, D.L., Engwerda, C., Fowkes, F.J.I., Grigg, M.J., Mueller, I., McCarthy, J.S., Anstey, N.M., and Beeson, J.G. (2019) IgM in human immunity to Plasmodium falciparum malaria. Science Advances, 5 (9). 4489.

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Abstract

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity.

Item ID: 60873
Item Type: Article (Research - C1)
ISSN: 2375-2548
Copyright Information: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Funders: National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), Channel 7 Children’s Research Foundation, Australian Centre of Research Excellence in Malaria Elimination, NHMRC, Wellcome Trust UK
Projects and Grants: NHMRC (GTN 1125656), NHMRC (GTN 1141632)
Date Deposited: 06 Nov 2019 07:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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