Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

Wang, Ruobing, Doolan, Denise L., Le, Thong P., Hedstrom, Richard C., Coonan, Kevin M., Charoenvit, Yupin, Jones, Trevor R., Hobart, Peter, Margalith, Michal, Ng, Jennifer, Weiss, Walter R., Sedegah, Martha, de Taisne, Charles, Norman, Jon A., and Hoffman, Stephen L. (1998) Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science, 282 (5388). pp. 476-480.

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Abstract

CD8⁺ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8⁺ T cell responses. Malaria-naı̈ve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8⁺ T cell–dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naı̈ve humans of the induction of CD8⁺ CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology.

Item ID: 42772
Item Type: Article (Refereed Research - C1)
ISSN: 1095-9203
Date Deposited: 21 Mar 2016 05:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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