Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates

Loukas, Alex, Gaze, Soraya, Pearson, Mark, Doolan, Denise, Felgner, Philip, Diemert, David, McManus, Donald P., Driguez, Patrick, and Bethony, Jeffrey (2012) Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates. In: Caffrey, Conor R., (ed.) Parasitic Helminths: targets, screens, drugs and vaccines. Drug Discovery in Infectious Diseases . Wiley-Blackwell, Weinheim, Germany, pp. 421-433.

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Vaccine development for schistosomiasis has had a chequered history. Many antigens that showed initial promise in murine models dropped by the wayside and only two vaccines are currently in clinical trials. In this chapter, we discuss antigen discovery in light of the "schistosomics" revolution, with a particular focus on immunomics, and undertake some crystal ball gazing on where all this information might lead us in the near future.We then discuss the transition of neglected tropical disease vaccines towards clinical trials via a public–private partnership model, using the discovery and preclinical development of the Sm-TSP-2 schistosomiasis vaccine as a case study.

Item ID: 34158
Item Type: Book Chapter (Research - B1)
ISBN: 978-3-527-65296-9
Keywords: schistosomiasis; vaccine; genomics; transcriptomics; proteomics; immunomics; Sm-TSP-2
Date Deposited: 28 Nov 2014 04:47
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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