Immune effector mechanisms in malaria

Good, Michael F., and Doolan, Denise L. (1999) Immune effector mechanisms in malaria. Current Opinion in Immunology, 11 (4). pp. 412-419.

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Abstract

Malaria, a disease responsible for immense human suffering, is caused by infection with Plasmodium spp. parasites, which have a very complex life cycle ntigenically unique stages infect different tissues of the body. This review details recent developments in our understanding of immunity both to preerythrocytic stage antigens and to erythrocytic stage antigens. The former is largely mediated via CD8⁺ T cells and involves IFN-γ, nitric oxide, IL-12 and natural killer cells; the latter varies (in different hosts and with different parasites) but is largely mediated by antibody, helper T cells, nitric oxide and γδ T cells. The recent progress towards clinical trials of vaccine candidates against both the pre-erythrocytic stage and erythrocytic stage is also summarized, in particular the use of heterologous prime/boost strategies for the former and the use of MSP1 as a candidate vaccine for the latter.

Item ID: 42771
Item Type: Article (Refereed Research - C1)
ISSN: 1879-0372
Funders: National Health and Medical Research Council (NHMRC), United Nations Development Programme (UNPD), World Health Organisation (WHO), Australian Centre for International and Tropical Health and Nutrition (ACITHN), Cooperative Research Centre for Vaccine Technology (CRCVT), Naval Medical Research and Development Command (NMRDC)
Projects and Grants: WHO Special Programme for Research and Training in Tropical Diseases
Date Deposited: 17 Mar 2016 04:11
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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