Non-toxic derivatives of LT as potent adjuvants

da Hora, Vanusa P., Conceição, Fabricio R., Dellagostin, Odir A., and Doolan, Denise L. (2011) Non-toxic derivatives of LT as potent adjuvants. Vaccine, 29 (8). pp. 1538-1544.

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Abstract

The heat-labile enterotoxin of Escherichia coli (LT) consists of an enzymatically active A subunit (LTA) and a pentameric B subunit (LTB). LT has been extensively studied as a potent modulator of immune responses but wild-type LT is toxic and therefore unsuitable for clinical use. Approaches pursued to avoid the toxicity associated with the use of the native toxin while retaining its adjuvant properties have included isolation of subunit B (LTB) and construction of non-toxic LT AB complex mutants, such as LTK63 mutant. Here we review the immunomodulatory characteristics of LTB and LTK63 and their potential as mucosal and parenteral vaccine adjuvants.

Item ID: 41446
Item Type: Article (Research - C1)
ISSN: 1873-2518
Keywords: adjuvant; LT; LTB; LTK63
Funders: National Health and Medical Research Council of Australia (NHMRC), Brazilian Ministry of Education (CAPES), Pfizer
Date Deposited: 11 Feb 2016 03:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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