Human challenge models: tools to accelerate the development of malaria vaccines

Cooper, Martha M., Loiseau, Claire, McCarthy, James S., and Doolan, Denise L. (2019) Human challenge models: tools to accelerate the development of malaria vaccines. Expert Review of Vaccines, 18 (3). pp. 241-251.

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Introduction: Malaria challenge models, where healthy human volunteers are intentionally infected with Plasmodium species parasites under controlled conditions, can be undertaken in several well-defined ways. These challenge models enable evaluation of the kinetics of parasite growth and clearance, host-pathogen interactions and the host immune response. They can facilitate discovery of candidate diagnostic biomarkers and novel vaccine targets. As translational tools they can facilitate testing of candidate vaccines and drugs and evaluation of diagnostic tests.

Areas covered: Until recently, malaria human challenge models have been limited to only a few Plasmodium falciparum strains and used exclusively in malaria-naïve volunteers in non-endemic regions. Several recent advances include the use of alternate P. falciparum strains and other species of Plasmodia, as well as strains attenuated by chemical, radiation or genetic modification, and the conduct of studies in pre-exposed individuals. Herein, we discuss how this diversification is enabling more thorough vaccine efficacy testing and informing rational vaccine development.

Expert opinion: The ability to comprehensively evaluate vaccine efficacy in controlled settings will continue to accelerate the translation of candidate malaria vaccines to the clinic, and inform the development and optimisation of potential vaccines that would be effective against multiple strains in geographically and demographically diverse settings.

Item ID: 57223
Item Type: Article (Research - C1)
ISSN: 1744-8395
Keywords: malaria, human challenge models, vaccines, drugs, diagnostics, tools
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Copyright Information: Copyright © 2019 Informa UK Limited, trading as Taylor & Francis Group
Additional Information:

A version of this publication was included as Chapter 1 of the following PhD thesis: Cooper, Martha Maria (2020) Molecular profiling of immunity to infectious disease using human challenge models. PhD thesis, James Cook University, which is available Open Access in ResearchOnline@JCU. Please see the Related URLs for access.

Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Principal Research Fellowship 1137285, NHMRC Practitioner Fellowship 1135955
Date Deposited: 07 Mar 2019 05:49
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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