Malaria DNA vaccines in Aotus monkeys

Gramzinski, Robert A., Maris, Dorina C., Doolan, Denise, Charoenvit, Yupin, Obaldia, Nicanor, Rossan, Richard, Sedegah, Martha, Wang, Ruobing, Hobart, Peter, Margalith, Michal, and Hoffman, Stephen (1997) Malaria DNA vaccines in Aotus monkeys. Vaccine, 15 (8). pp. 913-915.

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Abstract

In preparation for the development of DNA vaccines designed to produce protective antibodies against Plasmodium falciparum antigens (Ag), we conducted studies to optimize antibody responses in Aotus monkeys after immunization with the P. yoelli circumsporozoite (CSP) DNA vaccine. We demonstrate in Aotus monkeys that an intradermal route of immunization with a PyCSP plasmid DNA vaccine generates antibody responses equivalent to a multiple antigen peptide/adjuvant based vaccine, and that these data support the use of the intradermal route for initial studies of the efficacy of DNA vaccines in inducing protective antibodies against P. falciparum antigens in Aotus monkeys.

Item ID: 42774
Item Type: Article (Short Note)
Keywords: DNA vaccine; malaria; monkeys; Aotus; antibody
ISSN: 1873-2518
Funders: Naval Medical Research and Development Command (NMRDC), United States Army (USA)
Projects and Grants: NMDRC Work Unit 61102A.00101-BFX.1431, NMDRC Work Unit 6287A00101EFX.1432, USA Contract DAMD17-91-C-1072
Date Deposited: 13 Sep 2016 03:44
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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