Malaria vaccine design: immunological considerations

Good, Michael F., and Doolan, Denise L. (2010) Malaria vaccine design: immunological considerations. Immunity, 33 (4). pp. 555-566.

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Abstract

The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one. Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons. This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens. These and other concepts will be discussed in this review.

Item ID: 42727
Item Type: Article (Refereed Research - C1)
ISSN: 1097-4180
Funders: National Health and Medical Research Council (NHMRC) Australia, National Institutes of Health (NIH), USA, Rotarians Against Malaria (RAM), NHMRC Australia Fellowship, Pfizer Australia Senior Research Fellowship (PASRF)
Date Deposited: 23 Mar 2016 01:56
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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