T cell differentiation and lineage choice are determined by the TCR

Miles, John, Watkins, Thomas, Darko, Sam, Wijaya, Kuatrinnus, Cooper, Martha, Ransier, Amy, Waardenberg, Ashley, Amante, Fiona, Mccarthy, James, Price, David, Burrows, Scott, Doolan, Denise, Field, Matt, and Douek, Daniel (2022) T cell differentiation and lineage choice are determined by the TCR. FASEB Journal, 36 (S1).

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Next-generation sequencing technologies have revealed that adaptive immunity is underpinned by a vast array of T cell receptors (TCRs). However, it has proven difficult to interpret these extensive datasets, in part because the field previously lacked a comprehensive and internally controlled reference atlas encompassing the full spectrum of phenotypically defined subsets in each lineage. To address this knowledge gap, we sequenced 74 million TCRs expressed by discrete CD4+ and CD8+ memory T cell populations across genetically unrelated individuals, providing a resource to inform basic and applied studies of repertoire compartmentalisation within the adaptive immune system. Using this resource, we found that T cell differentiation could not be explained solely by the self-renewing effector model and, unexpectedly, that T cell fate could be predicted by specific genetic and physicochemical features of the TCR.

Item ID: 74503
Item Type: Article (Abstract)
ISSN: 1530-6860
Copyright Information: © 2022 Federation of American Societies for Experimental Biology (FASEB)
Additional Information:

Presented at the Experimental Biology meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract.

Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Project Grant 1069281
Date Deposited: 01 Nov 2022 01:33
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 100%
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