Defining the targets of antiparasitic compounds

Skinner-Adams, Tina S., Sumanadasa, Subathdrage D.M., Fisher, Gillian M., Davis, Rohan A., Doolan, Denise L., and Andrews, Katherine T. (2016) Defining the targets of antiparasitic compounds. Drug Discovery Today, 21 (5). pp. 725-739.

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Abstract

The treatment of major human parasitic infections is dependent on drugs that are plagued by issues of drug resistance. New chemotherapeutics with novel mechanisms of action (MOA) are desperately needed to combat multi-drug-resistant parasites. Although widespread screening strategies are identifying potential new hits for development against most major human parasitic diseases, in many cases such efforts are hindered by limited MOA data. Although MOA data are not essential for drug development, they can facilitate compound triage and provide a mechanism to combat drug resistance. Here we describe and discuss methods currently used to identify the targets of antiparasitic compounds, which could circumvent this bottleneck and facilitate the development of new antiparasitic drugs.

Item ID: 46656
Item Type: Article (Research - C1)
ISSN: 1878-5832
Funders: Australian National Health and Medical Research Council (NHMRC), Seventh Framework Programme (SFP)
Projects and Grants: NHMRC APP1074016, APP1098848, APP1102365 & APP1093378
Date Deposited: 14 Dec 2016 03:15
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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