Doolan, D.L., and Hoffman, S.L. (1997) Multi-gene vaccination against malaria: a multistage, multi-immune response approach. Parasitology Today, 13 (5). pp. 171-178.

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Abstract

An ideal malaria vaccine will induce immune responses against each stage of the Plasmodium spp life cycle. During its complicated life cycle, the parasite exists extracellularly in the host's bloodstream, within cells that express major histocompatibility complex (MHC) molecules (hepatocytes), within cells that do not express MHC molecules (erythrocytes) and within the mosquito vector. Different arms of the immune system are required to attack the parasite at the different stages. Therefore, a multistage vaccine must be a multi-immune response vaccine. In addition, given the unique antigenicities of the different stages of the life cycle, implicit in this definition is that the vaccine be multivalent. Here, Denise Doolan and Stephen Hoffman present the rationale for developing a multistage, multivalent, multi-immune response malaria vaccine and explain why, among currently available technologies, DNA vaccines may offer the best prospect for success.

Item ID:	42775
Item Type:	Article (Research - C1)
ISSN:	1471-5007
Funders:	Naval Medical Research and Development Command (NMRDC)
Projects and Grants:	NMDRC Work Unit 6287A00101EVX, NMDRC Work Unit 6287A00101EFX.1432, NMDRC Work Unit 61102A.00101-BFX.1431
Date Deposited:	14 Sep 2016 23:11
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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