Dichotomous miR expression and immune responses following primary blood-stage malaria

Burel, Julie G., Apte, Simon H., Groves, Penny L., Boyle, Michelle J., Langer, Christine, Beeson, James G., McCarthy, James S., and Doolan, Denise L. (2017) Dichotomous miR expression and immune responses following primary blood-stage malaria. JCI Insight, 2 (15). e93434. pp. 1-18.

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Abstract

Clinical responses to infection or vaccination and the development of effective immunity are characterized in humans by a marked interindividual variability. To gain an insight into the factors affecting this variability, we used a controlled human infection system to study early immune events following primary infection of healthy human volunteers with blood-stage Plasmodium falciparum malaria. By day 4 of infection, a dichotomous pattern of high or low expression of a defined set of microRNAs (miRs) emerged in volunteers that correlated with variation in parasite growth rate. Moreover, high-miR responders had higher numbers of activated CD4+ T cells, and developed significantly enhanced antimalarial antibody responses. Notably, a set of 17 miRs was identified in the whole blood of low-miR responders prior to infection that differentiated them from high-miR responders. These data implicate preexisting host factors as major determinants in the ability to effectively respond to primary malaria infection.

Item ID: 50030
Item Type: Article (Research - C1)
ISSN: 2379-3708
Funders: Medicines for Malaria Venture, Wellcome Trust, Bill and Melinda Gates Foundation, National Health and Medical Research Council (NHMRC) Australia, University of Queensland (UQ)
Projects and Grants: NHMRC grant 1037304, UQ International Scholarship, NHMRC Principal Research Fellowship, NHMRC Early Career Fellowship
Date Deposited: 04 Sep 2017 05:20
FoR Codes: 42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 25%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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