Recent advances in proteomic applications for schistosomiasis research: potential clinical impact

Sotillo, Javier, Doolan, Denise, and Loukas, Alex (2017) Recent advances in proteomic applications for schistosomiasis research: potential clinical impact. Expert Review of Proteomics, 14 (2). pp. 171-183.

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Abstract

Introduction: Schistosomiasis is a neglected tropical disease affecting hundreds of millions of people worldwide. Recent advances in the field of proteomics and the development of new and highly sensitive mass spectrometers and quantitative techniques have provided new tools for advancing the molecular biology, cell biology, diagnosis and vaccine development for public health threats such as schistosomiasis.

Areas covered: In this review we describe the latest advances in research that utilizes proteomics-based tools to address some of the key challenges to developing effective interventions against schistosomiasis. We also provide information about the potential of extracellular vesicles to advance the fight against this devastating disease.

Expert commentary: Different proteins are already being tested as vaccines against schistosomiasis with promising results. The re-analysis of the Schistosoma spp. proteomes using new and more sensitive mass spectrometers as well as better separation approaches will help identify more vaccine targets in a rational and informed manner. In addition, the recent development of new proteome microarrays will facilitate characterisation of novel markers of infection as well as new vaccine and diagnostic candidate antigens.

Item ID: 46714
Item Type: Article (Refereed Research - C1)
Keywords: schistosomiasis, schistosoma, proteomics, tegument, exosomes, schistosomula, vaccine, diagnostics, immunomics, secreted
ISSN: 1744-8387
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Program Grant 1037304, NHMRC Principal Reserach Fellowship 1020114
Date Deposited: 15 Jan 2017 22:42
FoR Codes: 06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 10%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060109 Proteomics and Intermolecular Interactions (excl Medical Proteomics) @ 70%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%
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