The rise of non-tuberculosis mycobacterial lung disease

Ratnatunga, Champa N., Lutzky, Viviana P., Kupz, Andreas, Doolan, Denise L., Reid, David W., Field, Matthew, Bell, Scott C., Thomson, Rachel M., and Miles, John J. (2020) The rise of non-tuberculosis mycobacterial lung disease. Frontiers in Immunology, 11. 303.

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Abstract

The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally. These lesser known “cousins” of Mycobacterium tuberculosis (TB) were once thought to be harmless environmental saprophytics and only dangerous to individuals with defective lung structure or the immunosuppressed. However, NTM are now commonly infecting seemingly immune competent children and adults at increasing rates through pulmonary infection. This is of concern as the pathology of NTM is difficult to treat. Indeed, NTM have become extremely antibiotic resistant, and now have been found to be internationally dispersed through person-to-person contact. The reasons behind this NTM increase are only beginning to be elucidated. Solutions to the problem are needed given NTM disease is more common in the tropics. Importantly, 40% of the world's population live in the tropics and due to climate change, the Tropics are expanding which will increase NTM infection regions. This review catalogs the global and economic disease burden, at risk populations, treatment options, host-bacterial interaction, immune dynamics, recent developments and research priorities for NTM disease.

Item ID: 62747
Item Type: Article (Research - C1)
ISSN: 1664-3224
Keywords: non-tuberculous mycobacteria, pulmonary infection, mycobacteria, immunology, mycobacteria pathology
Copyright Information: © 2020 Ratnatunga, Lutzky, Kupz, Doolan, Reid, Field, Bell, Thomson and Miles.
Funders: National Health and Medical Research Council (NHMRC), Queensland Health (QH), University of Queensland (UQ), James Cook University (JCU), Rebecca L Cooper Medical Research Foundation (RCMRF)
Projects and Grants: NHMRC CDF Level 2 Fellowship 1131732, QH Feollowships, UQ Research Training Program, JCU International Research Training Program Scholarship, RCMRF project grant #10509
Date Deposited: 29 Jun 2020 22:26
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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