DNA vaccines against malaria: immunogenicity and protection in a rodent model

Gardner, Malcolm J., Doolan, Denise L., Hedstrom, Richard C., Wang, Ruobing, Sedegah, Martha, Gramzinski, Robert A., Aguiar, Joao C., Wang, Helen, Margalith, Michal, Hobart, Peter, and Hoffman, Stephen L. (1996) DNA vaccines against malaria: immunogenicity and protection in a rodent model. Journal of Pharmaceutical Sciences, 85 (12). pp. 1294-1300.

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Since the first demonstration of the technology a few years ago, DNA vaccines have emerged as a promising method of vaccination. In a variety of experimental systems, DNA vaccines have been shown not only to induce potent immune responses, but also to offer many advantages in terms of ease of construction, testing, and production. In this article we summarize the progress achieved in development of DNA vaccines that can protect mice from infection by the rodent malaria parasite Plasmodium yoelii, describe initial studies of immunogenicity of a malaria DNA vaccine in a primate model, and outline the strategies being employed to design the next generation of malaria DNA vaccines.

Item ID: 42781
Item Type: Article (Research - C1)
ISSN: 1520-6017
Funders: Naval Medical Research and Development Command (NMRDC)
Projects and Grants: NMRDC Work Unit No. 62787A00101EVX, NMRDC Work Unit No. 61102A.00101-BFX, NMRDC Work Unit No. 62787A00101EFX
Date Deposited: 15 Sep 2016 01:40
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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