Immunomics: a 21st century approach to vaccine development for complex pathogens

De Sousa, Karina P., and Doolan, Denise L. (2016) Immunomics: a 21st century approach to vaccine development for complex pathogens. Parasitology, 143 (2). pp. 236-244.

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Abstract

Immunomics is a relatively new field of research which integrates the disciplines of immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the host-pathogen interface. Herein, we discuss how rapid advances in molecular immunology, sophisticated tools and molecular databases are facilitating in-depth exploration of the immunome. In our opinion, an immunomics-based approach presides over traditional antigen and vaccine discovery methods that have proved ineffective for highly complex pathogens such as the causative agents of malaria, tuberculosis and schistosomiasis that have evolved genetic and immunological host-parasite adaptations over time. By using an integrative multidisciplinary approach, immunomics offers enormous potential to advance 21st century antigen discovery and rational vaccine design against complex pathogens such as the Plasmodium parasite.

Item ID: 46647
Item Type: Article (Research - C1)
ISSN: 1469-8161
Keywords: immunomics, immunome, antigen discovery, rational vaccine design, vaccine development, parasites, malaria, complex pathogens
Funders: National Health and Medical Research Council (NHMRC), Pfizer Australia Senior Research Fellowship (PASRF)
Date Deposited: 15 Dec 2016 02:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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