Hedstrom, Richard C., and Doolan, Denise L. (2002) DNA vaccination. In: Doolan, Denise L., (ed.) Malaria Methods and Protocols. Methods in Molecular Medicine, 72 . Humana Press, New Jersey, NY, USA, pp. 347-360.

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Abstract

There is increasing recognition that the unique antigenicities of the different stages of the Plasmodium spp. life cycle, the requirement for distinct immune mechanisms targeting these different stages, the immense allelic variation of parasites in the field, and the genetic heterogeneity of the target population pose enormous obstacles to the development of a vaccine against malaria. It is likely that an efficacious vaccine will need to induce different immune responses against multiple targets expressed at distinct stages of the parasite's life cycle (i.e., a multivalent, multistage, multiimmune response vaccine) (1). However, how vaccines will be designed to produce protective broad-ranging immune responses has not been obvious based on conventional vaccine delivery systems.

Item ID:	42759
Item Type:	Book Chapter (Research - B1)
ISBN:	978-0-89603-823-3
ISSN:	1543-1894
Date Deposited:	29 Sep 2016 01:24
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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