Genome-based vaccine design: the promise for malaria and other infectious diseases

Doolan, Denise L., Apte, Simon H., and Proietti, Carla (2014) Genome-based vaccine design: the promise for malaria and other infectious diseases. International Journal for Parasitology, 44 (12). pp. 901-913.

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Vaccines are one of the most effective interventions to improve public health, however, the generation of highly effective vaccines for many diseases has remained difficult. Three chronic diseases that characterise these difficulties include malaria, tuberculosis and HIV, and they alone account for half of the global infectious disease burden. The whole organism vaccine approach pioneered by Jenner in 1796 and refined by Pasteur in 1857 with the "isolate, inactivate and inject" paradigm has proved highly successful for many viral and bacterial pathogens causing acute disease but has failed with respect to malaria, tuberculosis and HIV as well as many other diseases. A significant advance of the past decade has been the elucidation of the genomes, proteomes and transcriptomes of many pathogens. This information provides the foundation for new 21st Century approaches to identify target antigens for the development of vaccines, drugs and diagnostic tests. Innovative genome-based vaccine strategies have shown potential for a number of challenging pathogens, including malaria. We advocate that genome-based rational vaccine design will overcome the problem of poorly immunogenic, poorly protective vaccines that has plagued vaccine developers for many years.

Item ID: 41425
Item Type: Article (Research - C1)
ISSN: 1879-0135
Keywords: vaccine; rational vaccine design; genome-based; malaria; infectious diseases; 'Omics'
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©2014 The Authors. Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc. This is an open access article under the CC BY-NC-ND license (

Funders: National Health and Medical Research Council (NHMRC) Australia, Pfizer Australia Senior Research Fellowship (PASRF)
Date Deposited: 23 Mar 2016 04:02
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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