Publications by:
John J. Miles
Also publishes as (John Miles, J.J. Miles)
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Karunathilaka, Amali, Halstrom, Samuel, Price, Patricia, Holt, Michael, Lutzky, Viviana P., Doolan, Denise L., Kupz, Andreas, Bell, Scott C., Thomson, Rachel M., Miles, John J., and Ratnatunga, Champa N. (2022) CD161 expression defines new human γδ T cell subsets. Immunity & Ageing, 19. 11.
Ratnatunga, Champa N., Tungatt, Katie, Proietti, Carla, Halstrom, Sam, Holt, Michael R., Lutzky, Viviana P., Price, Patricia, Doolan, Denise L., Bell, Scott C., Field, Matt A., Kupz, Andreas, Thomson, Rachel M., and Miles, John J. (2022) Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease. Frontiers in Immunology, 13. 1047781.
Wong, Yide, Meehan, Michael, Burrows, Scott, Doolan, Denise, and Miles, John (2022) Estimating the global burden of Epstein–Barr virus‑related cancers. Journal of Cancer Research and Clinical Oncology, 148. pp. 31-46.
Cobos, Claudia, Bansal, Paramjit S., Wilson, David T., Jones, Linda, Zhao, Guangzu, Field, Matthew A., Eichenberger, Ramon M., Pickering, Darren A., Ryan, Rachael Y.M., Ratnatunga, Champa N., Miles, John J., Ruscher, Roland, Giacomin, Paul R., Navarro, Severine, Loukas, Alex, and Daly, Norelle L. (2022) Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells. Frontiers in Medicine, 9. 934852.
Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael, and Forbes, Josephine M. (2022) Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9). pp. 1994-2008.
Miles, John, Watkins, Thomas, Darko, Sam, Wijaya, Kuatrinnus, Cooper, Martha, Ransier, Amy, Waardenberg, Ashley, Amante, Fiona, Mccarthy, James, Price, David, Burrows, Scott, Doolan, Denise, Field, Matt, and Douek, Daniel (2022) T cell differentiation and lineage choice are determined by the TCR. FASEB Journal, 36 (S1).
Weerakoon, Harshi, Miles, John J., Lepletier, Ailin, and Hill, Michelle M. (2022) A high-resolution mass spectrometry based proteomic dataset of human regulatory T cells. Data in Brief, 40. 107687.
Moral-Sanz, Javier, Fernandez-Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Asa, Vila, Sabela F., Cabezas-Sainz, Pablo, Wilhelm, Patrick, Vela-Sebastian, Ana, Fernandez-Carrasco, Isabel, Chin, Yanni K.Y., Lopez-Mancheno, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J., and Ikonomopoulou, Maria P. (2022) The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAF(V600E). British Journal of Pharmacology, 179 (20). pp. 4878-4896.
Moral-Sanz, Javier, Fernandez-Rojo, Manuel A., Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., Alewood, Paul F., Waddell, Nicola, Miles, John J., Mulvenna, Jason P., and Ikonomopoulou, Maria P. (2021) ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations. Toxins, 13 (2). 146.
Weerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M., and Lepletier, Ailin (2021) Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9). e1334.
Haigh, Oscar L., Grant, Emma J., Nguyen, Thi H.O., Kedzierska, Katherine, Field, Matt A., and Miles, John J. (2021) Genetic bias, diversity indices, physiochemical properties and CDR3 motifs divide auto-reactive from allo-reactive T-Cell repertoires. International Journal of Molecular Sciences, 22 (4). 1625.
Ryan, Rachael Y.M., Seymour, Jamie, Loukas, Alex, Lopez, J. Alejandro, Ikonomopoulou, Maria P., and Miles, John J. (2021) Immunological responses to envenomation. Frontiers in Immunology, 12. 661082.
Smallwood, Taylor B., Navarro, Severine, Cristofori-Armstrong, Ben, Watkins, Thomas S., Tungatt, Katie, Ryan, Rachael Y.M., Haigh, Oscar L., Lutzky, Viviana P., Mulvenna, Jason P., Rosengren, Karl Johan, Loukas, Alex, Miles, John J., and Clark, Richard J. (2021) Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. Journal of Biological Chemistry, 297 (1). 100834.
Hewavisenti, Rehana V., Ferguson, Angela L., Gasparini, Georgia, Ohashi, Tomoki, Braun, Asolina, Watkins, Thomas S., Miles, John J., Elliott, Michael, Sierro, Frederic, Feng, Carl G., Britton, WarwicK J., Gebhardt, Thomas, Tangye, Stuart, and Palendira, Umaimainthan (2021) Tissue-resident regulatory T cells accumulate at human barrier lymphoid organs. Immunology & Cell Biology, 99 (8). pp. 894-906.
Saggiomo, Silvia L., Firth, Cadhla, Wilson, David T., Seymour, Jamie, Miles, John J., and Wong, Yide (2021) The geographic distribution, venom components, pathology and treatments of stonefish (Synanceia spp.) venom. Marine Drugs, 19 (6). 302.
Watkins, Thomas S., and Miles, John J. (2021) The human T-cell receptor repertoire in health and disease and potential for omics integration. Immunology and Cell Biology, 99 (2). pp. 135-145.
Ryan, Rachael Y.M., Fernandez, Alejandra, Wong, Yide, Miles, John J., and Cock, Ian E. (2021) The medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes. Scientific Reports, 11 (1). 5519.
Pearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E., Ladell, Kristin, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A., Tunger, Antje, Schmitz, Marc, Miles, John, Lahoud, Mireille H., and Radford, Kristen J. (2020) Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology, 9 (6). e1141.
Schmidt, Casey A., Wilson, David T., Cooke, Ira, Potriquet, Jeremy, Tungatt, Katie, Muruganandah, Visai, Boote, Chloe, Kuek, Felicity, Miles, John J., Kupz, Andreas, Ryan, Stephanie, Loukas, Alex, Bansal, Paramjit S., Takjoo, Rozita, Miller, David J., Peigneur, Steve, Tytgat, Jan, and Daly, Norelle (2020) Identification and characterization of a peptide from the stony coral Heliofungia actiniformis. Journal of Natural Products, 83 (11). pp. 3454-3463.
Tarbe, Marion, Miles, John J., Edwards, Emily S. J., Miles, Kim M., Sewell, Andrew K., Baker, Brian M., and Quideau, Stéphane (2020) Synthesis and biological evaluation of hapten-clicked analogues of the antigenic peptide Melan-A/MART-1₂₆₍₂₇L₎₋₃₅. ChemMedChem, 15 (9). pp. 799-807.
Ryan, Rachael Y.M., Lutzky, Viviana P., Herzig, Volker, Smallwood, Taylor B., Potriquet, Jeremy, Wong, Yide, Masci, Paul, Lavin, Martin F., King, Glenn F., Lopez, J. Alejandro, Ikonomopoulou, Maria P., and Miles, John J. (2020) Venom of the red-bellied black snake Pseudechis porphyriacus shows immunosuppressive potential. Toxins, 12 (11). 674.
Piontek, Melissa, Seymour, Jamie E., Wong, Yide, Gilstrom, Tyler, Potriquet, Jeremy, Jennings, Ernest, Nimmo, Alan, and Miles, John J. (2020) The pathology of Chironex fleckeri venom and known biological mechanisms. Toxicon, 6. 100026.
Weerakoon, Harshi, Potriquet, Jeremy, Shah, Alok K., Reed, Sarah, Jayakody, Buddhika, Kapil, Charu, Midha, Mukul K., Moritz, Robert L., Lepletier, Ailin, Mulvenna, Jason, Miles, John J., and Hill, Michelle M. (2020) A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics. Scientific Data, 7 (1). 412.
Ratnatunga, Champa N., Lutzky, Viviana P., Kupz, Andreas, Doolan, Denise L., Reid, David W., Field, Matthew, Bell, Scott C., Thomson, Rachel M., and Miles, John J. (2020) The rise of non-tuberculosis mycobacterial lung disease. Frontiers in Immunology, 11. 303.
Hayward, Tanisha A., Zhu, Gu, Warrington, Nicole M., Wong, Yide, Ryan, Rachael Y.M., Murray, Abella M., Haigh, Oscar, Martin, Nicholas G., Miles, John J., and Evans, David M. (2019) Antibody response to common human viruses is shaped by genetic factors. The Journal of Allergy and Clinical Immunology, 143 (4). pp. 1640-1643.
Vuckovic, Slavica, Minnie, Simone A., Smith, David, Gartlan, Kate H., Watkins, Thomas S., Markey, Kate A., Mukhopadhyay, Pamela, Guillerey, Camille, Kuns, Rachel D., Locke, Kelly R., Pritchard, Antonia L., Johansson, Peter A., Varelias, Antiopi, Zhang, Ping, Huntington, Nicholas D., Waddell, Nicola, Chesi, Marta, Miles, John J., Smyth, Mark J., and Hill, Geoffrey R. (2019) Bone marrow transplantation generates T cell–dependent control of myeloma in mice. Journal of Clinical Investigation, 129 (1). pp. 106-121.
Holt, Michael R., Miles, John J., Inder, Warrick J., and Thomson, Rachel (2019) Exploring immunomodulation by endocrine changes in Lady Windermere Syndrome. Clinical and Experimental Immunology, 196 (1). pp. 28-38.
Wangchuk, Phurpa, Shepherd, Catherine, Constantinoiu, Constantin, Ryan, Rachael Y.M., Kouremenos, Konstantinos A., Becker, Luke, Jones, Linda, Buitrago, Geraldine, Giacomin, Paul, Wilson, David, Daly, Norelle, Mcconville, Malcolm J., Miles, John J., and Loukas, Alex (2019) Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes. Infection and Immunity, 87 (4). e00851-18.
Law, Soi Cheng, Haigh, Oscar L., Walpole, Carina M., Colm, Keane, Miles, John J., Ghandi, Maher K., Radford, Kristen J., and Steptoe, Raymond J. (2019) Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies. Journal of Immunological Methods, 465. pp. 72-76.
Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E., Cole, David K., and Sewell, Andrew K. (2019) TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology, 49 (7). pp. 1052-1066.
Lepletier, Ailin, Lutzky, Viviana P., Mittal, Deepak, Stannard, Kimberley, Watkins, Thomas, Ratnatunga, Champa N., Smith, Corey, McGuire, Helen M., Kemp, Roslyn A., Mukhopadhyay, Pamela, Waddell, Nicola, Smyth, Mark J., Dougall, William C., and Miles, John J. (2019) The immune checkpoint CD96 defines a distinct lymphocyte phenotype and is highly expressed on tumor-infiltrating T cells. Immunology and Cell Biology, 97 (2). pp. 152-164.
Ikonomopoulou, Maria P., Fernandez-Rojo, Manuel A., Pineda, Sandy S., Cabezas-Sainz, Pablo, Winnen, Brit, Morales, Rodrigo A.V., Brust, Andreas, Sánchez, Laura, Alewood, Paul F., Ramm, Grant A., Miles, John, and King, Glenn F. (2018) Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation. Scientific Reports, 8.
Lutzky, Viviana P., Ratnatunga, Champa N., Smith, Daniel J., Kupz, Andreas, Doolan, Denise, Reid, David W., Thomson, Rachel M., Bell, Scott B., and Miles, John J. (2018) Anomalies in T cell function are associated with individuals at risk of Mycobacterium abscessus complex infection. Frontiers in Immunology, 9. 1319.
Fernandez-Rojo, Manuel A., Deplazes, Evelyne, Pineda, Sandy S., Brust, Andreas, Marth, Tano, Wilhelm, Patrick, Martel, Nick, Ramm, Grant A., Mancera, Ricardo L., Alewood, Paul F., Woods, Gregory M., Belov, Katherine, Miles, John J., King, Glenn F., Ikonomopoulou, Maria P., and UNSPECIFIED (2018) Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell Death Discovery, 4. 19. pp. 1-11.
Jimenez, Rocio, Ikonomopoulou, Maria P., Lopez, J. Alejandro, and Miles, John J. (2018) Immune drug discovery from venoms. Toxicon, 141. pp. 18-24.
Tungatt, Katie, Dolton, Garry, Morgan, Sophie B., Attaf, Meriem, Fuller, Anna, Whalley, Thomas, Hemmink, Johanneke D., Porter, Emily, Szomolay, Barbara, Montoya, Maria, Hammond, John A., Miles, John J., Cole, David K., Townsend, Alain, Bailey, Mick, Rizkallah, Pierre J., Charleston, Bryan, Tchilian, Elma, and Sewell, Andrew K. (2018) Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens, 14 (5). e1007017.
Miles, John, Tan, Mai Ping, Dolton, Garry, Edwards, Emily S.J., Galloway, Sarah A.E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine, Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Grass, Stephanie, Rossjohn, Jamie, Burrows, Scott, Cole, David K., Price, David A., and Sewell, Andrew K. (2018) Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation, 128 (4). pp. 1569-1580.
Goldenberg, Jonathan, Cipriani, Vittoria, Jackson, Timothy N.W., Arbuckle, Kevin, Debono, Jordan, Dashevsky, Daniel, Panagides, Nadya, Ikonomopoulou, Maria P., Koludarov, Ivan, Li, Bin, Santana, Renan Castro, Nouwens, Amanda, Jones, Alun, Hay, Chris, Dunstan, Nathan, Allen, Luke, Bush, Brian, Miles, John J., Ge, Lilin, Kwok, Hang Fai, and Fry, Bryan G. (2018) Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis). Comparative Biochemistry and Physiology - Part C, 205. pp. 53-61.
Wun, Kwok S., Reijneveld, Josephine F., Cheng, Tan-Yun, Ladell, Kristin, Uldrich, Adam P., Le Nours, Jérôme, Miners, Kelly L., Mclaren, James E., Grant, Emma J., Haigh, Oscar L., Watkins, Thomas S., Suliman, Sara, Iwany, Sarah, Jimenez, Judith, Calderon, Roger, Tamara, Kattya L., Leon, Segundo R., Murray, Megan B., Mayfield, Jacob A., Altman, John D., Purcell, Anthony W., Miles, John J., Godfrey, Dale I., Gras, Stephanie, Price, David A., Rhijn, Ildiko Van, Moody, D. Branch, and Rossjohn, Jamie (2018) T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology, 19. pp. 397-406.
McGuire, Helen M., Watkins, Thomas S., Field, Matthew, Taylor, Sarah, Yasuyama, Nao, Farmer, Andrew, Miles, John J., and Fazekas de St. Groth, Barbara (2018) TCR deep sequencing of transgenic RAG-1-deficient mice reveals endogenous TCR recombination: a cause for caution. Immunology and Cell Biology, 96 (6). pp. 642-645.
Cole, David K., Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J., Bulek, Anna M., Bridgeman, John S., Miles, John J., Schauenburg, Andrea J.A., Beck, Konrad, Evavold, Brian D., Rizkallah, Pierre J., and Sewell, Andrew K. (2017) Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology, 8. 1503.
Smallwood, Taylor B., Giacomin, Paul R., Loukas, Alex, Mulvenna, Jason P., Clark, Richard J., and Miles, John J. (2017) Helminth immunomodulation in autoimmune disease. Frontiers in Immunology, 8. 453.
Panagides, Nadya, Jackson, Timothy N.W., Ikonomopoulou, Maria P., Arbuckle, Kevin, Pretzler, Rudolf, Yang, Daryl C., Ali, Syed A., Koludarov, Ivan, Dobson, James, Sanker, Brittany, Asselin, Angelique, Santana, Renan C., Hendrikx, Iwan, van der Ploeg, Harold, Tai-A-Pin, Jeremie, van den Bergh, Romilly, Kerkkamp, Harald M.I., Vonk, Freek J., Naude, Arno, Strydom, Morne A., Jacobsz, Louis, Dunstan, Nathan, Jaeger, Marc, Hodgson, Wayne C., Miles, John, and Fry, Bryan G. (2017) How the cobra got its flesh-eating venom: cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting. Toxins, 9 (3). 103.
Minoda, Yoshihito, Virshup, Isaac, Rojas, Ingrid Leal, Haigh, Oscar, Wong, Yide, Miles, John J., Wells, Christine A., and Radford, Kristen J. (2017) Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Frontiers in Immunology, 8. 1419.
Cole, David K., Van Den Berg, Hugo A., Lloyd, Angharad, Crowther, Michael D., Beck, Konrad, Ekeruche-Makinde, Julia, Miles, John J., Bulek, Anna M., Dolton, Garry, Schauenburg, Andrea J., Wall, Aaron, Fuller, Anna, Clement, Mathew, Laugel, Bruno, Rizkallah, Pierre J., Wooldridge, Linda, and Sewell, Andrew K. (2017) Structural mechanism underpinning cross-reactivity of a CD8(+) T-cell clone that recognizes a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry, 292 (3). pp. 802-813.
Watkins, Thomas S., and Miles, John J. (2017) Tracking the T-cell repertoire after adoptive therapy. Clinical & Translational Immunology, 6. e140.
Blake, Stephen J., Dougall, William C., Miles, John J., Teng, Michele W.L., and Smyth, Mark J. (2016) Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy. Clinical Cancer Research, 22 (21). pp. 5183-5188.
Karunarathne, Deshapriya, Horne-Debets, Joshua M., Huang, Johnny X., Faleiro, Rebecca, Leow, Chiuan Yee, Amante, Fiona, Watkins, Thomas S., Miles, John, Dwyer, Patrick J., Stacey, Katryn J., Yarski, Michael, Poh, Chek Meng, Lee, Jason S., Cooper, Matthew A., Rénia, Laurent, Richard, Derek, McCarthy, James S., Sharpe, Arlene H., and Wykes, Michelle N. (2016) Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4⁺ T cell immunity. Immunity, 45 (2). pp. 333-345.
Laugel, Bruno, Lloyd, Angharad, Meermeier, Erin W., Crowther, Michael D., Connor, Thomas R., Dolton, Garry, Miles, John J., Burrows, Scott R., Gold, Marielle C., Lewinsohn, David M., and Sewell, Andrew K. (2016) Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology, 197 (3). pp. 971-982.
Szomolay, Barbara, Liu, Jie, Brown, Paul E., Miles, John J., Clement, Mathew, Llewellyn-Lacey, Sian, Dolton, Garry, Ekeruche-Makinde, Julia, Lissina, Anya, Schauenburg, Andrea J., Sewell, Andrew K., Burrows, Scott R., Roederer, Mario, Price, David A., Wooldridge, Linda, and van den Berg, Hugo A. (2016) Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology, 94 (6). pp. 573-582.
Cole, David K., Bulek, Anna M., Dolton, Garry, Schauenberg, Andrea J., Szomolay, Barbara, Rittase, William, Trimby, Andrew, Jothikumar, Prithiviraj, Fuller, Anna, Skowera, Ania, Rossjohn, Jamie, Zhu, Cheng, Miles, John J., Peakman, Mark, Wooldridge, Linda, Rizkallah, Pierre J., and Sewell, Andrew K. (2016) Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation, 126 (6). pp. 2191-2204.
Blake, Stephen J., Stannard, Kimberley, Liu, Jing, Allen, Stacey, Yong, Michelle C.R., Mittal, Deepak, Aguilera, Amelia Roman, Miles, John J., Lutzky, Viviana P., Ferrari de Andrade, Lucas, Martinet, Ludovic, Colonna, Marco, Takeda, Kazuyoshi, Kühnel, Florian, Gurlevik, Engin, Bernhardt, Günter, Teng, Michele W.L., and Smyth, Mark J. (2016) Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discovery, 6 (4). pp. 446-459.
Theaker, Sarah M., Rius, Cristina, Greenshields-Watson, Alexander, Lloyd, Angharad, Trimby, Andrew, Fuller, Anna, Miles, John J., Cole, David K., Peakman, Mark, Sewell, Andrew K., and Dolton, Garry (2016) T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods, 430. pp. 43-50.
Smith, Corey, Brennan, Rebekah M., Tey, Siok-Keen, Smyth, Mark J., Burrows, Scott R., Miles, John J., Hill, Geoffrey R., and Khanna, Rajiv (2016) Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution. Journal of Virology, 90 (6). pp. 7497-7507.
Nguyen, Thi H.O., Bird, Nicola L., Grant, Emma J., Miles, John J., Thomas, Paul G., Kotsimbos, Tom C., Mifsud, Nicole A., and Kedzierska, Katherine (2016) Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients. Immunology and Cell Biology, 95. pp. 77-86.
Proietti, Carla, Zakrzewski , Martha , Watkins, Thomas S., Berger, Bernard, Hasan, Shihab, Ratnatunga, Champa N., Brion, Marie-Jo, Crompton, Peter D., Miles, John J., Doolan, Denise L., and Krause, Lutz (2016) Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) web-server. Scientific Reports, 6. 38178. pp. 1-15.
Dasari, Vijayendra, Schuessler, Andrea, Smith, Corey, Wong, Yide, Miles, John J., Smyth, Mark J., Ambalathingal, George, Francis, Ross, Campbell, Scott, Chambers, Daniel, and Khanna, Rajiv (2016) Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients. Molecular Therapy: methods & clinical development, 3. 16058.
Ando, Miki, Nishimura, Toshinobu, Yamazaki, Satoshi, Yamaguchi, Tomoyuki, Kawana-Tachikawa, Ai, Hayama, Tomonari, Nakauchi, Yusuke, Ando, Jun, Ota, Yasunori, Takahashi, Satoshi, Nishimura, Ken, Ohtaka, Manami, Nakanishi, Mahito, Miles, John J., Burrows, Scott R., Brenner, Malcolm K., and Nakauchi, Hiromitsu (2015) A safeguard system for induced pluripotent stem cell-derived rejuvenated T cell therapy. Stem Cell Reports, 5 (4). pp. 597-608.
Neller, Michelle A., Ladell, Kristin, McLaren, James E., Matthews, Katherine K., Gostick, Emma, Pentier, Johanne M., Dolton, Garry, Schauenburg, Andrea J.A., Koning, Dan, Fontaine Costa, Ana Isabel C.A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly, Clement, Mathew, Wooldridge, Linda, Cole, David K., van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David A., and Miles, John J. (2015) Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology, 93 (7). pp. 625-633.
Bian, Michael Lei, Haigh, Oscar, Munster, David, Harris, Mark, Cotterill, Andrew, Miles, John J., and Vuckovic, Slavica (2015) Reactivated CD4+Tm cells of T1D patients and siblings display an exaggerated effector phenotype with heightened sensitivity to activation-induced cell death. Diabetes, 64 (6). pp. 2161-2171.
Rist, Melissa J., Hibbert, Kelly M., Croft, Nathan P., Smith, Corey, Neller, Michelle A., Burrows, Jacqueline M., Miles, John J., Purcell, Anthony W., Rossjohn, Jamie, Gras, Stephanie, and Burrows, Scott R. (2015) T cell cross-reactivity between a highly immunogenic EBV epitope and a self-peptide naturally presented by HLA-B*18:01⁺ cells. Journal of Immunology, 194 (10). pp. 4668-4675.
Miles, John J., McCluskey, James, Rossjohn, Jamie, and Gras, Stephanie (2015) Understanding the complexity and malleability of T-cell recognition. Immunology and Cell Biology, 93 (5). pp. 433-441.
Rossjohn, Jamie, Gras, Stephanie, Miles, John J., Turner, Stephen J., Godfrey, Dale I., and McCluskey, James (2015) T cell antigen receptor recognition of antigen-presenting molecules. Annual Review of Immunology, 33. pp. 169-200.
Tungatt, Katie, Bianchi, Valentina, Crowther, Michael D., Powell, Wendy E., Schauenburg, Andrea J., Trimby, Andrew, Donia, Marco, Miles, John J., Holland, Christopher J., Cole, David K., Godkin, Andrew J., Peakman, Mark, Straten, Per Thor, Svane, Inge Marie, Sewell, Andrew K., and Dolton, Garry (2015) Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology, 194 (1). pp. 463-474.
Gold, Marielle C., McLaren, James E., Reistetter, Joseph A., Smyk-Pearson, Sue, Ladell, Kristin, Swarbrick, Gwendolyn M., Yu, Yik Y.L., Hansen, Ted H., Lund, Ole, Nielsen, Morten, Gerritsen, Bram, Kesmir, Can, Miles, John J., Lewinsohn, Deborah A., Price, David A., and Lewinsohn, David M. (2014) MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. The Journal of Experimental Medicine, 211 (8). pp. 1601-1610.
Dolton, G., Lissina, A., Skowera, A., Ladell, K., Tungatt, K., Jones, E., Kronenberg-Versteeg, D., Akpovwa, H., Pentier, J.M., Holland, C.J., Godkin, A.J., Cole, D.K., Neller, M.A., Miles, J.J., Price, D.A., Peakman, M., and Sewell, A.K. (2014) Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology, 177 (1). pp. 47-63.
Brennan, Rebekah M., Burrows, Jacqueline M., Elliott, Thomas, Neller, Michelle A., Gras, Stephanie, Rossjohn, Jamie, Miles, John J., and Burrows, Scott J. (2014) Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire. British Journal of Haematology, 166 (1). pp. 148-152.
Liu, Yu Chih, Chen, Zhenjun, Neller, Michelle A., Miles, John J., Purcell, Anthony W., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, and Gras, Stephanie (2014) A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism. Journal of Biological Chemistry, 289 (24). pp. 16688-16698.
Lau, Lei Shong, Fernandez-Ruiz, Daniel, Mollard, Vanessa, Sturm, Angelika, Neller, Michelle A., Cozijnsen, Anton, Gregory, Julia L., Davey, Gayle M., Jones, Claerwen M., Lin, Yi-Hsuan, Haque, Ashraful, Engwerda, Christian R., Nie, Catherine Q., Hansen, Diana S., Murphy, Kenneth M., Papenfuss, Anthony T., Miles, John J., Burrows, Scott R., de Koning-Ward, Tania, McFadden, Geoffrey I., Carbone, Francis R., Crabb, Brendan S., and Heath, William R. (2014) CD8⁺ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria. PLoS Pathogens, 10 (5). e1004135. pp. 1-16.
Smith, Corey, Gras, Stephanie, Brennan, Rebekah M., Bird, Nicola L., Valkenburg, Sophie A., Twist, Kelly-Anne, Burrows, Jacqueline M., Miles, John J., Chambers, Daniel, Bell, Scott, Campbell, Scott, Kedzierska, Katherine, Burrows, Scott R., Rossjohn, Jamie, and Khanna, Rajiv (2014) Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire. Scientific Reports, 4. 3993. pp. 1-10.
Neller, Michelle A., Santner-Nanan, Brigitte, Brennan, Rebekah M., Hsu, Peter, Joung, Steven, Nanan, Ralph, Burrows, Scott R., and Miles, John J. (2014) Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the fetal–maternal interface and the peripheral blood. Frontiers in Immunology, 5. 33. pp. 1-6.
Skowera, Ania, Ladell, Kristin, McLaren, James E., Dolton, Garry, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin M., Miles, John J., Sewell, Andrew K., Price, David A., and Peakman, Mark (2014) β-cell–specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes, 64 (3). pp. 916-925.
Nivarthi, Usha K., Gras, Stephanie, Kjer-Nielsen, Lars, Berry, Richard, Lucet, Isabelle S., Miles, John J., Tracy, Samantha L., Purcell, Anthony W., Bowden, David S., Hellard, Margaret, Rossjohn, Jamie, McCluskey, James, and Bharadwaj, Mandvi (2014) An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant. Journal of Immunology, 193 (11). pp. 5402-5413.
Li, Shuo, Lefranc, Marie-Paule, Miles, John J., Alamyar, Eltaf, Giudicelli, Véronique, Duroux, Patrice, Freeman, J. Douglas, Corbin, Vincent D.A., Scheerlinck, Jean-Pierre, Frohman, Michael A., Cameron, Paul U., Plebanski, Magdalena, Loveland, Bruce, Burrows, Scott, Papenfuss, Anthony T., and Gowans, Eric J. (2013) IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling. Nature Communications, 4. 2333. pp. 1-13.
Burrows, Scott R., and Miles, John J. (2013) Immune parameters to consider when choosing T-cell receptors for therapy. Frontiers in Immunology, 4. 229. pp. 1-6.
Rist, Melissa J., Theodossis, Alex, Croft, Nathan P., Neller, Michelle A., Welland, Andrew, Chen, Zhenjun, Sullivan, Lucy C., Burrows, Jacqueline M., Miles, John J., Brennan, Rebekah M., Gras, Stephanie, Khanna, Rajiv, Brooks, Andrew G., McCluskey, James, Purcell, Anthony W., Rossjohn, Jamie, and Burrows, Scott R. (2013) HLA peptide length preferences control CD8+ T cell responses. Journal of Immunology, 191 (2). pp. 561-571.
Patel, Onisha, Kjer-Nielsen, Lars, Le Nours, Jérôme, Eckle, Sidonia B.G., Birkinshaw, Richard, Beddoe, Travis, Corbett, Alexandra J., Liu, Ligong, Miles, John, Meehan, Bronwyn, Reantragoon, Rangsima, Sandoval-Romero, Maria L., Sullivan, Lucy C., Brooks, Andrew G., Chen, Zhenjun, Fairlie, David P., McCluskey, James, and Rossjohn, Jamie (2013) Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications, 4. 2142. pp. 1-9.
Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J.A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., and Cole, David K. (2013) T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry, 288 (26). pp. 18766-18775.
Motozono, Chihiro, Miles, John J., Hasan, Zafrul, Gatanaga, Hiroyuki, Meribe, Stanley C., Price, David A., Oka, Shinichi, Sewell, Andrew K., and Ueno, Takamasa (2013) CD8⁺ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE, 8 (6). e66152. pp. 1-6.
Pentier, Johanne M., Sewell, Andrew K., and Miles, John J. (2013) Advances in T-Cell epitope engineering. Frontiers in Immunology, 4. 133. pp. 1-4.
Liu, Yu Chih, Miles, John J., Neller, Michelle A., Gostick, Emma, Price, David A., Purcell, Anthony W., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, and Gras, Stephanie (2013) Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule. Journal of Biological Chemistry, 288 (22). pp. 15442-15454.
Ekeruche-Makinde, Julia, Miles, John J., van den Berg, Hugo A., Skowera, Ania, Cole, David K., Dolton, Garry, Schauenburg, Andrea J.A., Tan, Mai Ping, Pentier, Johanne M., Llewellyn-Lacey, Sian, Miles, Kim M., Bulek, Anna M., Clement, Mathew, Williams, Tamsin, Trimby, Andrew, Bailey, Mick, Rizkallah, Pierre, Rossjohn, Jamie, Peakman, Mark, Price, David A., Burrows, Scott R., Sewell, Andrew K., and Wooldridge, Linda (2013) Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood, 121 (7). pp. 1112-1123.
Koning, Dan, Costa, Ana I., Hoof, Ilka, Miles, John J., Nanlohy, Nening M., Ladell, Kristin, Matthews, Katherine K., Venturi, Vanessa, Schellens, Ingrid M.M., Borghans, Jose A.M., Kesmir, Can, Price, David A., and van Baarle, Debbie (2013) CD8⁺ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex. Journal of Immunology, 190 (3). pp. 931-939.
Neller, M.A., Burrows, J.M., Rist, M.J., Miles, J.J., and Burrows, S.R. (2013) High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology, 87 (1). pp. 697-700.
Neller, Michelle A., Sewell, Andrew k., Burrows, Scott R., and Miles, John J. (2012) Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification. British Journal of Haematology, 159 (3). pp. 370-373.
Ekeruche-Makinde, Julia, Clement, Mathew, Cole, David K., Edwards, Emily S.J., Ladell, Kristin, Miles, John, Matthews, Katherine K., Fuller, Anna, Lloyd, Katy A., Madura, Florian, Dolton, Garry M., Pentier, Johanne, Lissina, Anna, Gostick, Emma, Baxter, Tiffany K., Baker, Brian M., Rizkallah, Pierre J., Price, David A., Wooldridge, Linda, and Sewell, Andrew K. (2012) T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry, 287 (44). pp. 37269-37281.
Illing, Patricia T., Vivian, Julian P., Dudek, Nadine L., Kostenko, Lyudmila, Chen, Zhenjun, Bharadwaj, Mandvi, Miles, John J., Kjer-Nielsen, Lars, Gras, Stephanie, Williamson, Nicholas A., Burrows, Scott R., Purcell, Anthony W., Rossjohn, Jamie, and McCluskey, James (2012) Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature, 486 (7404). pp. 554-558.
Brennan, Rebekah M., Petersen, Jan, Neller, Michelle A., Miles, John J., Burrows, Jacqueline M., Smith, Corey, McCluskey, James, Khanna, Rajiv, Rossjohn, Jamie, and Burrows, Scott R. (2012) The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity. Journal of Immunology, 188 (6). pp. 2742-2748.
Bulek, Anna M., Cole, David K., Skowera, Ania, Dolton, Garry, Gras, Stephanie, Madura, Florian, Fuller, Anna, Miles, John J., Gostick, Emma, Price, David A., Drijfhout, Jan W., Knight, Robin R., Huang, Guo C., Lissin, Nikolai, Molloy, Peter E., Wooldridge, Linda, Jakobsen, Bent K., Rossjohn, Jamie, Peakman, Mark, Rizkallah, Pierre J., and Sewell, Andrew K. (2012) Structural basis of human β-cell killing by CD8⁺ T cells in Type 1 diabetes. Nature Immunology, 13 (3). pp. 283-289.
Wooldridge, Linda, Ekeruche-Makinde, Julia, van den Berg, Hugo A., Skowera, Anna, Miles, John J., Tan, Mai Ping, Dolton, Garry, Clement, Mathew, Llewellyn-Lacey, Sian, Price, David A., Peakman, Mark, and Sewell, Andrew K. (2012) A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry, 287 (2). pp. 1168-1177.
Smith, C., Miles, J.J., and Khanna, R. (2012) Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure. American Journal of Transplantation, 12 (1). pp. 15-26.
Bridgeman, John S., Sewell, Andrew K., Miles, John J., Price, David A., and Cole, David K. (2012) Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology, 135 (1). pp. 9-18.
Clement, Mathew, Ladell, Kristin, Ekeruche-Makinde, Julia, Miles, John J., Edwards, Emily S.J., Dolton, Garry, Williams, Tamsin, Schauenburg, Andrea J.A., Cole, David K., Lauder, Sarah N., Gallimore, Awen M., Godkin, Andrew J., Burrows, Scott R., Price, David A., Sewell, Andrew K., and Wooldridge, Linda (2011) Anti-CD8 Antibodies Can Trigger CD8⁺ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining. Journal of Immunology, 187 (2). pp. 654-663.
Miles, John J., Douek, Daniel C., and Price, David A. (2011) Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunology and Cell Biology, 89 (3). pp. 375-387.
Miles, John J., Thammanichanond, Duangtawan, Moneer, Sarah, Nivarthi, Usha K., Kjer-Nielsen, Lars, Tracy, Samantha L., Aitken, Campbell K., Brennan, Rebekah M., Zeng, Weiguang, Marquart, Louise, Jackson, David, Burrows, Scott R., Bowden, David S., Torresi, Joseph, Hellard, Margaret, Rossjohn, Jamie, McCluskey, James, and Bharadwaj, Mandvi (2011) Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection. Journal of Immunology, 186 (2). pp. 901-912.
Miles, Kim M., Miles, John J., Madura, Florian, Sewell, Andrew K., and Cole, David K. (2011) Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology, 48 (4). pp. 728-732.
Tarbe, Marion, Azcune, Itxaso, Balentová, Eva, Miles, John J., Edwards, Emily E., Miles, Kim M., Do, Priscilla, Baker, Brian M., Sewell, Andrew K., Aizpurua, Jesus M., Douat-Casassus, Céline, and Quideau, Stéphane (2010) Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media. Organic and Biomolecular Chemistry, 8 (23). pp. 5345-5353.
Miles, John J., Bulek, Anna M., Cole, David k., Gostick, Emma, Schauenburg, Andrea J.A., Dolton, Garry, Venturi, Vanessa, Davenport, Miles P., Tan, Mai Ping, Burrows, Scott, Wooldridge, Linda, Price, David A., Rizkallah, Pierre J., and Sewell, Andrew K. (2010) Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens, 6 (11). e1001198. pp. 1-15.
Cole, David K., Edwards, Emily S.J., Wynn, Katherine K., Clement, Mathew, Miles, John J., Ladell, Kristin, Ekeruche, Julia, Gostick, Emma, Adams, Katherine J., Skowera, Ania, Peakman, Mark, Wooldridge, Linda, Price, David A., and Sewell, Andrew K. (2010) Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. Journal of Immunology, 185 (4). pp. 2600-2610.
Gras, Stephanie, Chen, Zhenjun, Miles, John J., Liu, Yu Chih, Bell, Melissa J., Sullivan, Lucy C., Kjer-Nielsen, Lars, Brennan, Rebekah M., Burrows, Jacqueline M., Neller, Michelle A., Khanna, Rajiv, Purcell, Anthony W., Brooks, Andrew G., McCluskey, James, Rossjohn, Jamie, and Burrows, Scott R. (2010) Allelic polymorphism in the T cell receptor and its impact on immune responses. The Journal of Experimental Medicine, 207 (7). pp. 1555-1567.
Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, Anthony W., McCluskey, James, and Rossjohn, Jamie (2010) Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences, 107 (23). pp. 10608-10613.
Wooldridge, Linda, Clement, Mathew, Lissina, Anna, Edwards, Emily S.J., Ladell, Kristin, Ekeruche, Julia, Hewitt, Rachel E., Laugel, Bruno, Gostick, Emma, Cole, David K., Debets, Reno, Berrevoets, Cor, Miles, John J., Burrows, Scott R., Price, David A., and Sewell, Andrew K. (2010) MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology, 184 (7). pp. 3357-3366.
Cole, David K., Yuan, Fang, Rizkallah, Pierre J., Miles, John J., Gostick, Emma, Price, David A., Gao, George F., Jakobsen, Bent K., and Sewell, Andrew K. (2009) Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry, 284 (40). pp. 27281-27289.
Bell, Melissa J., Burrows, Jacqueline M., Brennan, Rebekah, Miles, John J., Tellam, Judy, McCluskey, James, Rossjohn, Jamie, Khanna, Rajiv, and Burrows, Scott R. (2009) The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in length. Molecular Immunology, 46 (8-9). pp. 1911-1917.
Miles, John J., Brennan, Rebekah M., and Burrows, Scott R. (2009) T cell receptor bias in humans. Current Immunology Reviews, 5 (1). pp. 10-21.
Archbold, Julia K., Macdonald, Whitney A., Gras, Stephanie, Ely, Lauren K., Miles, John J., Bell, Melissa J., Brennan, Rebekah M., Beddoe, Travis, Wilce, Matthew C.J., Clements, Craig S., Purcell, Anthony W., McCluskey, James, Burrows, Scott R., and Rossjohn, Jamie (2009) Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. The Journal of Experimental Medicine, 206 (1). pp. 209-219.
Bell, Melissa J., Brennan, Rebekah, Miles, John J., Moss, Denis J., Burrows, Jacqueline M., and Burrows, Scott R. (2008) Widespread sequence variation in Epstein‐Barr virus nuclear antigen 1 influences the antiviral T cell response. Journal of Infectious Diseases, 197 (11). pp. 1594-1597.
Wynn, Katherine K., Fulton, Zara, Cooper, Leanne, Silins, Sharon L., Gras, Stephanie, Archbold, Julia K., Tynan, Fleur E., Miles, John J., McCluskey, James, Burrows, Scott R., Rossjohn, Jamie, and Khanna, Rajiv (2008) Impact of clonal competition for peptide-MHC complexes on the CD8⁺ T-cell repertoire selection in a persistent viral infection. Blood, 111 (8). pp. 4283-4292.
Burrows, Jacqueline M., Bell, Melissa J., Brennan, Rebekah, Miles, John J., Khanna, Rajiv, and Burrows, Scott R. (2008) Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognition. Molecular Immunology, 45 (6). pp. 1818-1824.
Elliott, Suzanne L., Suhrbier, Andreas, Miles, John J., Lawrence, Greg, Pye, Stephanie J., Le, Thuy T., Rosenstengel, Andrew, Nguyen, Tam, Allworth, Anthony, Burrows, Scott R., Cox, John, Pye, David, Moss, Denis J., and Bharadwaj, Mandvi (2008) Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosis. Journal of Virology, 82 (3). pp. 1448-1457.
Brennan, Rebekah M., Miles, John J., Silins, Sharon L., Bell, Melissa J., Burrows, Jacqueline M., and Burrows, Scott R. (2007) Predictable αβ T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope. Journal of Virology, 81 (13). pp. 7269-7273.
Burrows, Jacqueline M., Wynn, Katherine K., Tynan, Fleur E., Archbold, Julia, Miles, John J., Bell, Melissa J., Brennan, Rebekah M., Walker, Susan, McCluskey, James, Rossjohn, Jamie, Khanna, Rajiv, and Burrows, Scott R. (2007) The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. European Journal of Immunology, 37 (4). pp. 946-953.
Tynan, Fleur E., Reid, Hugh H., Kjer-Nielsen, Lars, Miles, John J., Wilce, Matthew C.J., Kostenko, Lyudmila, Borg, Natalie A., Williamson, Nicholas A., Beddoe, Travis, Purcell, Anthony W., Burrows, Scott R., McCluskey, James, and Rossjohn, Jamie (2007) A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nature Immunology, 8 (3). pp. 268-276.
Miles, John J., Borg, Natalie A., Brennan, Rebekah M., Tynan, Fleur E., Kjer-Nielsen, Lars, Silins, Sharon L., Bell, Melissa J., Burrows, Jacqueline, McCluskey, James, Rossjohn, Jamie, and Burrows, Scott R. (2006) TCR genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. Journal of Immunology, 177 (10). pp. 6804-6814.
Archbold, Julia K., Macdonald, Whitney A., Miles, John J., Brennan, Rebekah M., Kjer-Nielsen, Lars, McCluskey, James, Burrows, Scott R., and Rossjohn, Jamie (2006) Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry. Journal of Biological Chemistry, 281 (45). pp. 34324-34332.
Miles, John J., Silins, Sharon L., and Burrows, Scott R. (2006) Engineered T cell receptors and their potential in molecular medicine. Current Medicinal Chemistry, 13 (23). pp. 2725-2736.
Miles, John J., Silins, Sharon L., Brooks, Andrew G., Davis, Joanne E., Misko, Ihor, and Burrows, Scott R. (2005) T-cell grit: large clonal expansions of virus-specific CD8⁺ T cells can dominate in the peripheral circulation for at least 18 years. Blood, 106 (13). pp. 4412-4413.
Tynan, Fleur E., Elhassen, Diah, Purcell, Anthony W., Burrows, Jacqueline M., Borg, Natalie A., Miles, John J., Williamson, Nicholas A., Green, Kate A., Tellam, Judy, Kjer-Nielsen, Lars, McCluskey, James, Rossjohn, Jamie, and Burrows, Scott r. (2005) The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. The Journal of Experimental Medicine, 202 (9). pp. 1249-1260.
Miles, John J., Elhassen, Diah, Borg, Natalie A., Silins, Sharon L., Tynan, Fleur E., Burrows, Jacqueline M., Purcell, Anthony W., Kjer-Nielsen, Lars, Rossjohn, Jamie, Burrows, Scott R., and McCluskey, James (2005) CTL recognition of a bulged viral peptide involves biased TCR selection. Journal of Immunology, 175 (6). pp. 3826-3834.
Tynan, Fleur E., Borg, Natalie A., Miles, John J., Beddoe, Travis, El-Hassen, Diah, Silins, Sharon L., van Zuylen, Wendy J.M., Purcell, Anthony W., Kjer-Nielsen, Lars, McCluskey, James, Burrows, Scott R., and Rossjohn, Jamie (2005) High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-cell receptor engagement and T-cell immunodominance. Journal of Biological Chemistry, 280 (25). pp. 23900-23909.
Ely, Lauren K., Green, Katherine J., Beddoe, Travis, Clements, Craig S., Miles, John J., Bottomley, Stephen P., Zernich, Danielle, Kjer-Nielsen, Lars, Purcell, Anthony W., McCluskey, James, Rossjohn, Jamie, and Burrows, Scott R. (2005) Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection. Journal of Immunology, 174 (9). pp. 5593-5601.
Borg, Natalie A., Ely, Lauren K., Beddoe, Travis, Macdonald, Whitney A., Reid, Hugh H., Clements, Craig S., Purcell, Anthony W., Kjer-Nielsen, Lars, Miles, John J., Burrows, Scott R., McCluskey, James, and Rossjohn, Jamie (2005) The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nature Immunology, 6 (2). pp. 171-180.
Tynan, Fleur E., Burrows, Scott R., Buckle, Ashley M., Clements, Craig S., Borg, Natalie A., Miles, John J., Beddoe, Travis, Whisstock, James C., Wilce, Matthew C., Silins, Sharon L., Burrows, Jacqueline M., Kjer-Nielsen, Lars, Kostenko, Lyudmila, Purcell, Anthony W., McCluskey, James, and Rossjohn, Jamie (2005) T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I–bound peptide. Nature Immunology, 6 (11). pp. 1114-1122.
Tellam, Judy, Connolly, Geoff, Green, Katherine J., Miles, John J., Moss, Denis J., Burrows, Scott R., and Khanna, Rajiv (2004) Endogenous presentation of CD8+T cell epitopes from Epstein-Barr virus–encoded nuclear antigen 1. The Journal of Experimental Medicine, 199 (10). pp. 1421-1431.
Lew, Ala E., Bock, Russell E., Miles, John, Cuttell, Leigh B., Steer, Penelope, and Nadin-Davis, Susan A. (2004) Sensitive and specific detection of bovine immunodeficiency virus and bovine syncytial virus by 5' Taq nuclease assays with fluorescent 3' minor groove binder-DNA probes. Journal of Virological Methods, 116 (1). pp. 1-9.
Burrows, Scott R., Elkington, Rebecca A., Miles, John J., Green, Katherine J., Walker, Susan, Haryana, Sofia M., Moss, Denis J., Dunckley, Heather, Burrows, Jacqueline M., and Khanna, Rajiv (2003) Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertype. Journal of Immunology, 171 (3). pp. 1407-1412.