Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

Miles, John J., Douek, Daniel C., and Price, David A. (2011) Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunology and Cell Biology, 89 (3). pp. 375-387.

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The naïve T-cell repertoire is vast, containing millions of unique T-cell receptor (TCR) structures. Faced with such diversity, the mobilization of TCR structures from this enormous pool was once thought to be a stochastic, even chaotic, process. However, steady and systematic dissection over the last 20 years has revealed that this is not the case. Instead, the TCR repertoire deployed against individual antigens is routinely ordered and biased. Often, identical and near-identical TCR repertoires can be observed across different individuals, suggesting that the system encompasses an element of predictability. This review provides a catalog of αβ TCR bias by disease and by species, and discusses the mechanisms that govern this inherent and widespread phenomenon.

Item ID: 45203
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: T cells; T-cell receptor; TCR repertoire
Date Deposited: 17 Aug 2016 01:50
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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