Engineered T cell receptors and their potential in molecular medicine

Miles, John J., Silins, Sharon L., and Burrows, Scott R. (2006) Engineered T cell receptors and their potential in molecular medicine. Current Medicinal Chemistry, 13 (23). pp. 2725-2736.

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T cell receptors are among the most specific biological structures found in nature and are therefore excellent candidates for the molecular targeting of antigen. It is becoming increasingly apparent that common sets of T cell receptors are frequently used in humans to combat pathogen and cancer derived threats. Given that many of these conserved T cell receptors have high affinity for their target ligands, there is potential to amass virtual banks of off-the-shelf receptors for use in a wide range of immunotherapeutic strategies. Additionally, such T cell receptors could become basic blueprints for artificial enhancement through mutagenesis, thereby creating an even better 3-dimensional fit for their cognate targets. Indeed, preliminary approaches using both natural and supernatural T cell receptors have shown promise in treating autoimmunity and malignancy. This review will discuss these studies and other approaches through which T cell receptors can be exploited in immunodiagnostics, pathogen control and gene therapy.

Item ID: 45403
Item Type: Article (Research - C1)
ISSN: 1875-533X
Keywords: T cell receptor, immunotherapy, major histocompatibility complex, human leucocyte antigens
Date Deposited: 12 Sep 2016 01:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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