Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure

Smith, C., Miles, J.J., and Khanna, R. (2012) Advances in direct T-cell alloreactivity: function, avidity, biophysics and structure. American Journal of Transplantation, 12 (1). pp. 15-26.

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Abstract

Although T-cell-based adaptive immunity plays a crucial role in protection against infectious pathogens and uncontrolled outgrowth of malignant cells, a large portion of these T cells are also capable of responding to allogeneic HLA molecules, violating the paradigm of self-major histocompatibility complex (MHC) restriction. Recent studies have provided insights into the mechanisms by which these T cells recognize allogeneic targets. The role of antiviral T cells in direct alloreactivity through peptide-dependent molecular mimicry and alternate peptide-MHC docking modes has emerged as major models for the human alloresponse. Here, we review in depth recent advances in this field and discuss how molecular interactions between T cells and HLA molecules drive the activation of these effector cells and its potential implications for alloreactivity in human transplantation.

Item ID: 45199
Item Type: Article (Research - C1)
ISSN: 1600-6143
Keywords: alloreactivity; alloreactive T cells; allorecognition; bone marrow; HLA antigens; memory T cells; transplant; transplant immunobiology; viral immunity; viral infection
Funders: National Health and Medical Research Council (NHMRC), Wales Office of Research and Development (WORD), Roche Organ Transplantation Research Foundation (ROTRF)
Date Deposited: 17 Aug 2016 02:02
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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