Antibody response to common human viruses is shaped by genetic factors

Hayward, Tanisha A., Zhu, Gu, Warrington, Nicole M., Wong, Yide, Ryan, Rachael Y.M., Murray, Abella M., Haigh, Oscar, Martin, Nicholas G., Miles, John J., and Evans, David M. (2018) Antibody response to common human viruses is shaped by genetic factors. The Journal of Allergy and Clinical Immunology. (In Press)

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Abstract

Significant interindividual variation exists among “normal” human humoral immune responses to viral infection. However, although the genetic etiology of immunologic extremes such as primary immunodeficiency has been well characterized, little is known about the genetics of normal interindividual variation in immune response. The classical twin design, which compares the phenotypic similarity between monozygotic (MZ) twin pairs and dizygotic (DZ) twin pairs, can be used to estimate the proportion of interindividual variation due to genetic factors. For example, the classical twin design has been used to demonstrate that antibody response to vaccination against certain pathogens is likely to be influenced by genetic factors.1 The present study used twin and sibling data to estimate the genetic and environmental determinants of antibody titers to 6 common human viruses: EBV, Coxsackie B virus (CVB), parvovirus B-19 (PV-B19), herpes simplex virus 1 (HSV-1), human herpes virus 6 (HHV-6), and cytomegalovirus (CMV). Although these viruses usually cause relatively mild symptoms or are asymptomatic, many are also observationally associated with the development of more severe diseases, including autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus.2

Item ID: 57182
Item Type: Article (Research - C1)
ISSN: 1097-6825
Copyright Information: Copyright © 2018 American Academy of Allergy, Asthma & Immunology
Funders: National Health and Medical Research Council (NHMRC), Australian Infectious Diseases Network (AIDN)
Projects and Grants: NHMRC APP1125141, NHMRC Senior Research Fellowship (grant no. APP1137714), NHMRC Career Development Fellowship (grant no. APP1131732), NHMRC Early Career Fellowship (grant no. APP1104818), AIDN seed grant
Date Deposited: 26 Feb 2019 23:26
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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