T cell receptor bias in humans

Miles, John J., Brennan, Rebekah M., and Burrows, Scott R. (2009) T cell receptor bias in humans. Current Immunology Reviews, 5 (1). pp. 10-21.

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The last decade has seen escalating reports of T cell receptor (TcR) bias across all facets of human immunity. These reports describe a phenomenon whereby certain peptide-bound major histocompatibility complexes (pMHC) elicit T cell expansions which bear TcRs with identical or near-identical sequences across unrelated individuals. These observations are indeed curious given the vastness of the naive T cell repertoire and indicate that powerful Darwinian selection forces influence both thymic and post-thymic pMHC-driven selection. This review catalogues examples of selection bias in the human αβ T cell response and presents the proposed mechanisms that steer their supremacy in the blood.

Item ID: 45388
Item Type: Article (Research - C1)
ISSN: 1875-631X
Keywords: T cell receptor, T cell repertoire, immunodominance, major histocompatibility complex, peptide
Date Deposited: 18 Jan 2018 02:23
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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