The geographic distribution, venom components, pathology and treatments of stonefish (Synanceia spp.) venom

Saggiomo, Silvia L., Firth, Cadhla, Wilson, David T., Seymour, Jamie, Miles, John J., and Wong, Yide (2021) The geographic distribution, venom components, pathology and treatments of stonefish (Synanceia spp.) venom. Marine Drugs, 19 (6). 302.

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Stonefish are regarded as one of the most venomous fish in the world. Research on stonefish venom has chiefly focused on the in vitro and in vivo neurological, cardiovascular, cytotoxic and nociceptive effects of the venom. The last literature review on stonefish venom was published over a decade ago, and much has changed in the field since. In this review, we have generated a global map of the current distribution of all stonefish (Synanceia) species, presented a table of clinical case reports and provided up-to-date information about the development of polyspecific stonefish antivenom. We have also presented an overview of recent advancements in the biomolecular composition of stonefish venom, including the analysis of transcriptomic and proteomic data from Synanceia horrida venom gland. Moreover, this review highlights the need for further research on the composition and properties of stonefish venom, which may reveal novel molecules for drug discovery, development or other novel physiological uses.

Item ID: 68394
Item Type: Article (Research - C1)
ISSN: 1660-3397
Keywords: stonefish; Synanceia; venom; toxins; pharmacology; distribution
Copyright Information: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Funders: James Cook University (JCU), Australian National Health and Medical Research Council (NHMRC)
Projects and Grants: Higher Degree of Research (HDR) COVID-19 Student Support Scholarship, JCU College of Public Health, Medical and Veterinary Sciences Scholarship, JCU HDR Enhancement Scheme Grant, NHMRC (1131932) - The HOT North Initiative, NHMRC Career Development Fellowship (1131732)
Date Deposited: 14 Jun 2021 01:24
FoR Codes: 42 HEALTH SCIENCES > 4206 Public health > 420699 Public health not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 100%
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