Structural and biophysical determinants of αβ T-cell antigen recognition

Bridgeman, John S., Sewell, Andrew K., Miles, John J., Price, David A., and Cole, David K. (2012) Structural and biophysical determinants of αβ T-cell antigen recognition. Immunology, 135 (1). pp. 9-18.

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Abstract

The molecular rules that govern MHC restriction, and allow T-cells to differentiate between peptides derived from healthy cells and those from diseased cells, remain poorly understood. Here we provide an overview of the structural constraints that enable the T-cell receptor (TCR) to discriminate between self and non-self peptides, and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide-major histocompatibility complex (pMHC) binding with T-cell activation. We further review how the antigenic origin of peptide epitopes affects TCR binding parameters and the 'quality' of a T-cell response. Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity.

Item ID: 45194
Item Type: Article (Research - C1)
ISSN: 1365-2567
Keywords: biophysics, crystal structure, peptide-major histocompatibility complex, T-cell activation, T-cell receptor
Funders: Wales Office of Research and Development (WORD), Medical Research Council (MRC), Wellcome Trust (WT)
Date Deposited: 16 Aug 2016 05:36
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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