Immune drug discovery from venoms

Jimenez, Rocio, Ikonomopoulou, Maria P., Lopez, J. Alejandro, and Miles, John J. (2018) Immune drug discovery from venoms. Toxicon, 141. pp. 18-24.

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This review catalogues recent advances in knowledge on venoms as standalone therapeutic agents or as blueprints for drug design, with an emphasis on venom-derived compounds that affects the immune system. We discuss venoms and venom-derived compounds that affect total immune cell numbers, immune cell proliferation, immune cell migration, immune cell phenotype and cytokine secretion. Identifying novel compounds that 'tune' the system, up-regulating the immune response during infectious disease and cancer and down-regulating the immune response during autoimmunity, will greatly expand the tool kit of human immunotherapeutics. Targeting these pathways may also open therapeutic options that alleviate symptoms of envenomation. Finally, combining recent advances in venomics with progress in low cost, high-throughput screening platforms will no doubt yield hundreds of prototype immune modulating compounds in the coming years. (C) 2017 Elsevier Ltd. All rights reserved.

Item ID: 52531
Item Type: Article (Research - C1)
ISSN: 1879-3150
Keywords: Venom, Toxin, Therapeutic, Immune modulation, Immune system
Copyright Information: Copyright ©2017 Elsevier Ltd.
Funders: Perpetual IMPACT Program, Australian National Health and Medical Research Council (NHMRC)
Projects and Grants: Perpetual IMPACT Program (IDIPAP2015/1585), NHMRC 1131732
Date Deposited: 14 Feb 2018 07:49
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 100%
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