The human T-cell receptor repertoire in health and disease and potential for omics integration

Watkins, Thomas S., and Miles, John J. (2021) The human T-cell receptor repertoire in health and disease and potential for omics integration. Immunology and Cell Biology, 99 (2). pp. 135-145.

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Abstract

The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cancers that look to consume our resources. This review describes the genetics and architecture of the human TCR and highlights surprising new discoveries over the past years that have disproved very old dogmas. The standardization of TCR sequencing data is discussed in preparation for big data bioinformatics and predictive analysis. We next catalogue new signatures and phenomenon discovered by TCR next generation sequencing (NGS) in health and disease and work that remain to be done in this space. Finally, we discuss how TCR NGS can add to immunodiagnostics and integrate with other omics platforms for both a deeper understanding of TCR biology and its use in the clinical setting.

Item ID: 66032
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: T cell; T-cell genetics; T-cell receptor; T-cell receptor sequencing; T-cell repertoire.
Copyright Information: (C) 2020 The Authors. Immunology & Cell Biology published by John Wiley &Sons Australia, Ltd on behalf of Australian and New Zealand Society forImmunology, Inc.
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC Grant no. 1131732, NHMRC Grant no. 613664, NHMRC Grant no. 1021620, NHMRC Grant no. 1069281, NHMRC Grant no. 1106756
Date Deposited: 21 Jun 2021 00:20
FoR Codes: 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310199 Biochemistry and cell biology not elsewhere classified @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100%
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