Helminth immunomodulation in autoimmune disease

Smallwood, Taylor B., Giacomin, Paul R., Loukas, Alex, Mulvenna, Jason P., Clark, Richard J., and Miles, John J. (2017) Helminth immunomodulation in autoimmune disease. Frontiers in Immunology, 8.

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Abstract

Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating "talents" of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.

Item ID: 50459
Item Type: Article (Research - C1)
ISSN: 1664-3224
Keywords: helminthic therapy, autoimmunity, immunomodulation, excretory/secretory products, immunotherapy
Additional Information:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Funders: Australian Postgraduate Award, Australian Research Council (ARC), Australian Infectious Disease Research Centre, National Cancer Institute (NCI), National Health and Medical Research Council (NHMRC), Advance Queensland Fellowship, Career Development Fellowship (GDF)
Projects and Grants: ARC Future Fellowship grant FT100100476, NCI grant number R01CA155297, NHMRC Senior Principle Research Fellowship grant 1117505, CDF grant number 1031652, CDF grant number 1051627
Date Deposited: 20 Sep 2017 09:18
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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