High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

Neller, M.A., Burrows, J.M., Rist, M.J., Miles, J.J., and Burrows, S.R. (2013) High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology, 87 (1). pp. 697-700.

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Abstract

High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.

Item ID: 45181
Item Type: Article (Research - C1)
ISSN: 1098-5514
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC APP1031652, NHMRC APP1021452, NHMRC APP389830
Date Deposited: 16 Aug 2016 04:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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