Tracking the T-cell repertoire after adoptive therapy

Watkins, Thomas S., and Miles, John J. (2017) Tracking the T-cell repertoire after adoptive therapy. Clinical & Translational Immunology, 6. e140.

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[Extract] In recent years, there has been increased interest in using immunotherapy to treat cancer. Adoptive T-cell therapy (ACT) involves the isolation and expansion of tumour-specific T cells in vitro. Large numbers of tumour-specific T cells are then infused back into cancer patients to provide a substantial 'boost' to anti-cancer immunity. While this personalised therapy has shown promise across various cancer settings, response rates still vary and significant energy is currently being invested into understanding the immunology underpinning these diverse clinical outcomes. Indeed, the burning question at present is how do you identify an effective ACT product from ineffective? Chaouis et al. recently probed this question by tracking ACT products using T-cell receptor (TCR) deep sequencing. Using pre- and post-infusion samples from melanoma, breast cancers and Merkel cell carcinoma patients, the authors'tracked clonotypes in the days to months post infusion and compared clonotype parameters with clinical parameters.

Item ID: 53103
Item Type: Article (Commentary)
ISSN: 2050-0068
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