Understanding the complexity and malleability of T-cell recognition

Miles, John J., McCluskey, James, Rossjohn, Jamie, and Gras, Stephanie (2015) Understanding the complexity and malleability of T-cell recognition. Immunology and Cell Biology, 93 (5). pp. 433-441.

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View at Publisher Website: http://dx.doi.org/10.1038/icb.2014.112


T cells are the master regulators of immune system function, continually walking the biological tightrope between adequate host defence and accidental host pathology. Tolerance is maintained or broken through an intricate structural interplay between the T-cell receptor (TCR) and major histocompatibility complex (MHC) molecule cradling peptide antigens (p). Recent advances in structural biology have shown that the TCR/pMHC interface is surprising precise and extraordinarily malleable. We have seen that seemingly minor changes in the TCR/pMHC interface can abrogate function, as well as substantial conformational changes before and after TCR docking. Our understanding of T-cell biology has also been altered with the knowledge that MHC molecules can bind not only peptides, but also an array of natural and synthetic compounds. Here, we review some examples of the precision and flexibility intrinsic to the TCR/p/MHCI axis.

Item ID: 45052
Item Type: Article (Research - C1)
ISSN: 1440-1711
Funders: National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), Roche Organ Transplantation Research Fund
Projects and Grants: ARC Future Fellowship
Date Deposited: 11 Aug 2016 03:05
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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