Tackling fish allergy: bio-molecular studies on allergenic proteins causing fish allergy in Australian children for improved diagnosis
Ruethers, Thimo (2020) Tackling fish allergy: bio-molecular studies on allergenic proteins causing fish allergy in Australian children for improved diagnosis. PhD thesis, James Cook University.
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Abstract
Allergy to fish is life-threatening and a lifelong immune disease. Current diagnostics are unreliable, which is further complicated by thousands of edible species. The allergen composition of over 100 Asia-Pacific fish species was investigated and 23 novel allergens registered. Findings are translated into improved diagnostics and management, including personalised medicine.
| Item ID: | 77038 |
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| Item Type: | Thesis (PhD) |
| Keywords: | allergens and epitopes, allergy diagnosis, allergy management, Asia-Pacific, basophil activation, bony fish, canned fish, cartilaginous fish, cod, collagen, Crocodylus porosus crustacean allergy, fish allergy diagnosis, fish allergy, fish cross-reactivity, food allergy, food challenge, food labeling, food safety, IgE antibody, IgE binding, IgE cross-linking, IgE reactivity, IgE, immunilogic tests, mollusc allergy, paediatrics, Pangasianodon hypophthalmus, PARV-19, parvalbumin, prevention, ray, Salmo salar, skin prick test, triosephosphate isomerase, tropomyosin |
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| Copyright Information: | Copyright © 2020 Thimo Ruethers. |
| Additional Information: | This is a thesis by publication. Published versions of articles included as Chapters II, III A and IV, as well as Appendices D1 and D3, have been redacted from the thesis due to copyright restrictions. Seven publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: [Chapter I] Ruethers, Thimo, Taki, Aya C., Johnston, Elecia B., Nugraha, Roni, Le, Thu T.K., Kalic, Tanja, McLean, Thomas R., Kamath, Sandip D., and Lopata, Andreas L. (2018) Seafood allergy: a comprehensive review of fish and shellfish allergens. Molecular Immunology, 100. pp. 28-57. [Chapter II] Ruethers, Thimo, Taki, Aya C., Nugraha, Roni, Cao, Truc T., Koeberl, Martina, Kannath, Sandip D., Williamson, Nicholas A., O'Callaghan, Sean, Nie, Shuai, Mehr, Sam S., Cannpbell, Dianne E., and Lopata, Andreas L. (2019) Variability of allergens in commercial fish extracts for skin prick testing. Allergy, 74 (7). pp. 1352-1363. [Chapter III A] Ruethers, Thimo, Taki, Aya C., Khangurha, Jasmit, Roberts, James, Buddhadasa, Saman, Clarke, Dean, Hedges, Claire E., Campbell, Dianne E., Kamath, Sandip D., Lopata, Andreas L., and Koeberl, Martina (2020) Commercial fish ELISA kits have a limited capacity to detect different fish species and their products. Journal of the Science of Food and Agriculture, 100 (12). pp. 4353-4363. [Chapter IV] Ruethers, T., Raith, M., Sharpe, M.F., Koeberl, M., Stephen, J.N., Nugraha, R., Le, T.T.K., Quirce, S., Nguyen, H.X.M., Kamath, S.D., Mehr, S.S., Campbell, D.E., Bridges, C.R., Taki, A.C., Swoboda, I., and Lopata, A.L. (2018) Characterization of Ras k 1 a novel major allergen in Indian mackerel and identification of parvalbumin as the major fish allergen in 33 Asia-Pacific fish species. Clinical & Experimental Allergy, 48 (4). pp. 452-463. [Chapter V A] Ruethers, Thimo, Taki, Aya C., Karnaneedi, Shaymaviswanathan, Nie, Shuai, Kalic, Tanja, Dai, Danyi, Daduang, Sakda, Leeming, Michael, Williamson, Nicholas A., Breiteneder, Heimo, Mehr, Sam S., Kamath, Sandip, Campbell, Dianne E., and Lopata, Andreas (2021) Expanding the allergen repertoire of salmon and catfish. Allergy, 76 (5). pp. 1443-1453. [Chapter V B] Kalic, Tanja, Kamath, Sandip D., Ruethers, Thimo, Taki, Aya C., Nugraha, Roni, Le, Thu T.K., Humeniuk, Piotr, Williamson, Nicholas A., Hira, Diamond, Rolland, Jennifer M., O'Hehir, Robyn E., Dai, Danyi, Campbell, Dianne E., Breiteneder, Heimo, and Lopata, Andreas L. (2020) Collagen-an important fish allergen for improved diagnosis. Journal Of Allergy And Clinical Immunology: In Practice, 8 (9). pp. 3084-3092. [Chapter VI A] Kalic, Tanja, Morel-Codreanu, Francoise, Radauer, Christian, Ruethers, Thimo, Taki, Aya C., Swoboda, Ines, Higer, Christiane, Hoffmann-Sommergruber, Karin, Ollert, Markus, Hafner, Christine, Lopata, Andreas L., Morisset, Martine, Breiteneder, Heimo, and Kuehn, Annette (2019) Patients allergic to fish tolerate ray based on the low allergenicity of its parvalbumin. Journal Of Allergy And Clinical Immunology: In Practice, 7 (2). pp. 500-508. |
| Date Deposited: | 14 Dec 2022 00:20 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 40% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 30% 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3006 Food sciences > 300605 Food safety, traceability, certification and authenticity @ 30% |
| SEO Codes: | 20 HEALTH > 2004 Public health (excl. specific population health) > 200405 Food safety @ 50% 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 50% |
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