Mechanisms driving tuberculosis susceptibility and vaccine efficacy in HIV/AIDS and type 2 diabetes

Sathkumara, Harindra Darshana (2020) Mechanisms driving tuberculosis susceptibility and vaccine efficacy in HIV/AIDS and type 2 diabetes. PhD thesis, James Cook University.

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View at Publisher Website: https://doi.org/10.25903/ct0z-we98
 
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Abstract

Harindra Sathkumara investigated why AIDS and diabetes increase the risk of developing tuberculosis and how new vaccine approaches can be used to fight tuberculosis infection. He found that mucosal delivery of vaccines containing Mycobacterium tuberculosis antigens are safer and confer superior protection against tuberculosis in animal models of AIDS and diabetes.

Item ID: 76795
Item Type: Thesis (PhD)
Keywords: tuberculosis, AIDS, diabetes, vaccines, mucosal delivery, animal models
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Copyright Information: Copyright ©2020 Harindra Darshana Sathkumara.
Additional Information:

For this thesis, Harindra Sathkumara received the Dean's Award for Excellence 2021.

Six publications relating to this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are:

[Chapter 3] Sathkumara, Harindra D., Pai, Saparna, de Jesús Aceves-Sánchez, Michel, Ketheesan, Natkunam, Flores-Valdez, Mario Alberto, and Kupz, Andreas (2019) BCG vaccination prevents reactivation of latent lymphatic murine tuberculosis independently of CD4+ T cells. Frontiers in Immunology, 10. 532.

[Chapter 4] Sathkumara, Harindra D., Muruganandah, Visai, Cooper, Martha M., Field, Matt A., Alim, Md Abdul, Brosch, Roland, Ketheesan, Natkunam, Govan, Brenda, Rush, Catherine M., Henning, Lars, and Kupz, Andreas (2020) Mucosal delivery of ESX-1–expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes. National Academy of Sciences. Proceedings, 117 (34). pp. 20848-20859.

[Chapter 5] Sathkumara, Harindra D., Hansen, Karyina, Miranda-Hernandez, Socorro, Govan, Brenda, Rush, Catherine M., Henning, Lars, Ketheesan, Natkunam, and Kupz, Andreas (2020) Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and nondiabetic mice. Antimicrobial Agents and Chemotherapy, 65 (1). e01422-20.

[Appendix 1] Muruganandah, Visai, Sathkumara, Harindra D., Pai, Saparna, Rush, Catherine M., Brosch, Roland, Waardenberg, Ashley J., and Kupz, Andreas (2020) A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies. Science Advances, 6 (10).

[Appendix 2] Alim, Md Abdul, Sikder, Suchandan, Sathkumara Mudiyanselage, Harindra, Kupz, Andreas, Rush, Catherine M., Govan, Brenda L., and Ketheesan, Natkunam (2019) Dysregulation of key cytokines may contribute to increased susceptibility of diabetic mice to Mycobacterium bovis BCG infection. Tuberculosis, 115. pp. 113-120.

[Appendix 3] Muruganandah, Visai, Sathkumara, Harindra D., Navarro, Severine, and Kupz, Andreas (2018) A systematic review: the role of resident memory T cells in infectious diseases and their relevance for vaccine development. Frontiers in Immunology, 9. 1574. pp. 1-21.

Date Deposited: 15 Nov 2022 03:35
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 30%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320407 Innate immunity @ 30%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 40%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50%
28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50%
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