Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and nondiabetic mice

Sathkumara, Harindra D., Hansen, Karyina, Miranda-Hernandez, Socorro, Govan, Brenda, Rush, Catherine M., Henning, Lars, Ketheesan, Natkunam, and Kupz, Andreas (2020) Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and nondiabetic mice. Antimicrobial Agents and Chemotherapy, 65 (1). e01422-20.

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View at Publisher Website: https://doi.org/10.1128/AAC.01422-20


Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

Item ID: 65796
Item Type: Article (Research - C1)
ISSN: 0066-4804
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Copyright Information: (C) American Society for Microbilogy
Additional Information:

A version of this publication was included as Chapter 5 of the following PhD thesis: Sathkumara, Harindra Darshana (2020) Mechanisms driving tuberculosis susceptibility and vaccine efficacy in HIV/AIDS and type 2 diabetes. PhD thesis, James Cook University, which is available Open Access in ResearchOnline@JCU. Please see the Related URLs for access.

Funders: National Health and Medical Research Council (NHMRC), Australian Institute of Tropical Health and Medicine (AITHM)
Projects and Grants: NHMRC APP1052764, NHMRC APP1140709, NRMRC APP1120808, AITHM 15031
Date Deposited: 02 Mar 2021 00:18
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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