Characterising the role of fructose metabolism in hepatocellular carcinoma
Dewdney, Brittany (2021) Characterising the role of fructose metabolism in hepatocellular carcinoma. PhD thesis, James Cook University.
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Abstract
Brittany Dewdney examined the effects of fructose sugar on primary liver cancer metabolism and tumour growth. She found that fructose reduced liver cancer growth and increased the efficacy of two novel metabolism-inhibiting drugs on restricting tumour growth in an animal model. This work provides novel information about liver tumour metabolism that contradicts the current literature that suggests fructose promotes fatty liver disease and liver cancer.
| Item ID: | 75798 |
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| Item Type: | Thesis (PhD) |
| Keywords: | hepatocellular carcinoma, liver cancer, non-alcoholic fatty liver disease, malignant hepatoma, cell metabolism, fructose, Hormad2, tumour growth |
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| Copyright Information: | Copyright © 2021 Brittany Dewdney. |
| Additional Information: | Two publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: Chapter 1: Dewdney, Brittany, Roberts, Alexandra, Qiao, Liang, George, Jacob, and Hebbard, Lionel (2020) A sweet connection? Fructose’s role in hepatocellular carcinoma. Biomolecules, 10 (4). 496. Chapter 3: Dewdney, Brittany, Alanzay, Mohammed, Gillman, Rhys, Walker, Sarah, Wankell, Miriam, Qiao, Liang, George, Jacob, Roberts, Alex, and Hebbard, Lionel (2020) The effects of fructose and metabolic inhibition on hepatocellular carcinoma. Scientific Reports, 10. 16769. |
| Date Deposited: | 23 Aug 2022 03:49 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321111 Solid tumours @ 35% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 35% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310103 Cell metabolism @ 30% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 50% |
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