A sweet connection? Fructose’s role in hepatocellular carcinoma

Dewdney, Brittany, Roberts, Alexandra, Qiao, Liang, George, Jacob, and Hebbard, Lionel (2020) A sweet connection? Fructose’s role in hepatocellular carcinoma. Biomolecules, 10 (4). 496.

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Abstract

Hepatocellular carcinoma is one of few cancer types that continues to grow in incidence and mortality worldwide. With the alarming increase in diabetes and obesity rates, the higher rates of hepatocellular carcinoma are a result of underlying non-alcoholic fatty liver disease. Many have attributed disease progression to an excess consumption of fructose sugar. Fructose has known toxic effects on the liver, including increased fatty acid production, increased oxidative stress, and insulin resistance. These effects have been linked to non-alcoholic fatty liver (NAFLD) disease and a progression to non-alcoholic steatohepatitis (NASH). While the literature suggests fructose may enhance liver cancer progression, the precise mechanisms in which fructose induces tumor formation remains largely unclear. In this review, we summarize the current understanding of fructose metabolism in liver disease and liver tumor development. Furthermore, we consider the latest knowledge of cancer cell metabolism and speculate on additional mechanisms of fructose metabolism in hepatocellular carcinoma.

Item ID: 63878
Item Type: Article (Research - C1)
ISSN: 2218-273X
Keywords: Fructose, liver cancer, hepatocellular carcinoma
Copyright Information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Funders: Cancer Council Queensland (CCQ), James Cook University (JCU), University of Sydney (US), National Health and Medical Research Council of Australia (NHMRC).
Projects and Grants: CCQ project grant APP1123436, JCU International Postgraduate Research Scholarship, US Storr Trust, JCU Rising Star Grant, NHMRC Practitioner Fellowship
Date Deposited: 28 Jul 2020 02:51
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321111 Solid tumours @ 50%
31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310103 Cell metabolism @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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