Genetic characterization of archived bunyaviruses and their potential for emergence in Australia

Huang, Bixing, Firth, Cadhla, Watterson, Daniel, Allcock, Richard, Colmant, Agathe M.G., Hobson-Peters, Jody, Kirkland, Peter, Hewitson, Glen, Mcmahon, Jamie, Hall-Mendelin, Sonja, van den Hurk, Andrew F., and Warrilow, David (2016) Genetic characterization of archived bunyaviruses and their potential for emergence in Australia. Emerging Infectious Diseases, 22 (5). pp. 833-840.

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Abstract

To better understand the diversity of bunyaviruses and their circulation in Australia, we sequenced 5 viruses (Gan Gan, Trubanaman, Kowanyama, Yacaaba, and Taggert) isolated and serologically identified 4 decades ago as members of the family Bunyaviridae. Gan Gan and Trubanaman viruses almost perfectly matched 2 recently isolated, purportedly novel viruses, Salt Ash and Murrumbidgee viruses, respectively. Kowanyama and Yacaaba viruses were identified as being related to members of a large clade containing pathogenic viruses. Taggert virus was confirmed as being a nairovirus; several viruses of this genus are pathogenic to humans. The genetic relationships and historical experimental infections in mice reveal the potential for these viruses to lead to disease emergence.

Item ID: 59902
Item Type: Article (Research - C1)
ISSN: 1080-6059
Funders: Queensland Health
Date Deposited: 16 Sep 2019 01:28
FoR Codes: 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310509 Genomics @ 50%
31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310706 Virology @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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