Comparative and transcriptome analyses uncover key aspects of coding-and long noncoding RNAs in flatworm mitochondrial genomes

Ross, Eric, Blair, David, Guerrero-Hernández, Carlos, and Sánchez Alvarado, Alejandro (2016) Comparative and transcriptome analyses uncover key aspects of coding-and long noncoding RNAs in flatworm mitochondrial genomes. G3 Genes Genomes Genetics, 6 (5). pp. 1191-1200.

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Abstract

Exploiting the conservation of various features of mitochondrial genomes has been instrumental in resolving phylogenetic relationships. Despite extensive sequence evidence, it has not previously been possible to conclusively resolve some key aspects of flatworm mitochondrial genomes, including generally conserved traits, such as start codons, noncoding regions, the full complement of tRNAs, and whether ATP8 is, or is not, encoded by this extranuclear genome. In an effort to address these difficulties, we sought to determine the mitochondrial transcriptomes and genomes of sexual and asexual taxa of freshwater triclads, a group previously poorly represented in flatworm mitogenomic studies. We have discovered evidence for an alternative start codon, an extended cox1 gene, a previously undescribed conserved open reading frame, long noncoding RNAs, and a highly conserved gene order across the large evolutionary distances represented within the triclads. Our findings contribute to the expansion and refinement of mitogenomics to address evolutionary issues in this diverse group of animals.

Item ID: 47797
Item Type: Article (Refereed Research - C1)
Keywords: Platyhelminthes; mitochondria; Schmidtea mediterranea; atp8; lncRNAs
Additional Information:

Copyright © 2016 Ross et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ISSN: 2160-1836
Date Deposited: 21 Mar 2017 05:04
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060409 Molecular Evolution @ 50%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060407 Genome Structure and Regulation @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%
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