Micallef, Michelle A., and Garg, Manohar L. (2008) The Lipid-Lowering Effects of Phytosterols and (n-3) Polyunsaturated Fatty Acids Are Synergistic and Complementary in Hyperlipidemic Men and Women. The Journal of Nutrition, 138 (6). pp. 1086-1090.

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Abstract

Fish oils rich in (n-3) long-chain PUFA (LCPUFA) can reduce circulating triglycerides and raise HDL-cholesterol. Phytosterols have been shown to reduce total cholesterol and LDL-cholesterol in normocholesterolemic and hyperlipidemic populations. We investigated the combined effects of phytosterols and (n-3) LCPUFA on plasma lipid profile in hyperlipidemic individuals. This study was a 3-wk randomized, double-blind, placebo-controlled, 2 × 2 factorial trial in 4 parallel groups of 60 hyperlipidemic individuals. Subjects were randomized to receive either sunola oil or 1.4 g/d (n-3) LCPUFA capsules with or without 2 g phytosterols per day while maintaining their habitual diet. The combination of phytosterols and (n-3) LCPUFA reduced plasma total cholesterol by 13.3% (P = 0.001), which differed from (n-3) LCPUFA alone (P < 0.001). LDL-cholesterol concentrations followed the same pattern as that of plasma cholesterol with a 12.5% decrease (P = 0.002) in the combination group. The HDL-cholesterol concentration was increased by (n-3) LCPUFA (7.1%; P = 0.01) alone and in combination with phytosterols (8.6%; P = 0.04), whereas phytosterol treatment alone had no effect. Plasma triglyceride concentration was lowered by (n-3) LCPUFA (22.3%; P = 0.004) alone and in combination with phytosterols (25.9%; P = 0.005), whereas phytosterol treatment alone had no effect. In conclusion, the combined supplementation with phytosterols and (n-3) LCPUFA has both synergistic and complementary lipid-lowering effects in hyperlipidemic men and women.

Item ID:	81291
Item Type:	Article (Research - C1)
ISSN:	1541-6100
Copyright Information:	© 2008 American Society for Nutrition.
Date Deposited:	21 Mar 2024 06:25
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321001 Clinical nutrition @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321003 Nutrigenomics and personalised nutrition @ 50%
SEO Codes:	20 HEALTH > 2004 Public health (excl. specific population health) > 200410 Nutrition @ 100%
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