Srivastava, Mansi, Simakov, Oleg, Chapman, Jarrod, Fahey, Bryony, Gauthier, Marie E.A., Mitros, Therese, Richards, Gemma S., Conaco, Cecilia, Dacre, Michael, Hellsten, Uffe, Larroux, Claire, Putnam, Nicholas H, Stanke, Mario, Adamska, Maja, Darling, Aaron, Degnan, Sandie M., Oakley, Todd H., Plachetzki, David C., Zhai, Yufeng, Adamski, Marcin, Calcino, Andrew, Cummins, Scott F., Goodstein, David M., Harris, Christina, Jackson, Daniel J., Leys, Sally P., Shu, Shengqiang, Woodcroft, Ben J., Vervoort, Michel, Kosik, Kenneth S., Manning, Gerard, Degnan, Bernard M., and Rokhsar, Daniel S. (2010) The Amphimedon queenslandica genome and the evolution of animal complexity. Nature, 466. pp. 720-726.

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Abstract

Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse 'toolkit' of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.

Item ID:	80260
Item Type:	Article (Research - C1)
ISSN:	1476-4687
Copyright Information:	©2010 Macmillan Publishers Limited. All rights reserved
Date Deposited:	29 Aug 2024 01:10
FoR Codes:	31 BIOLOGICAL SCIENCES > 3104 Evolutionary biology > 310404 Evolution of developmental systems @ 50% 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310509 Genomics @ 50%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
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