Cellular milieu in clear cell renal cell carcinoma

Raghubar, Arti M.M., Roberts, Matthew J., Wood, Simon, Healy, Helen G., Kassianos, Andrew J., and Mallett, Andrew J. (2022) Cellular milieu in clear cell renal cell carcinoma. Frontiers in Oncology, 12. 943583.

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Abstract

Clear cell renal cell carcinoma (ccRCC) is globally the most prevalent renal cancer. The cells of origin in ccRCC have been identified as proximal tubular epithelial cells (PTEC); however, the transcriptomic pathways resulting in the transition from normal to malignant PTEC state have remained unclear. Immunotherapy targeting checkpoints have revolutionized the management of ccRCC, but a sustained clinical response is achieved in only a minority of ccRCC patients. This indicates that our understanding of the mechanisms involved in the malignant transition and resistance to immune checkpoint therapy in ccRCC is unclear. This review examines recent single-cell transcriptomics studies of ccRCC to clarify the transition of PTEC in ccRCC development, and the immune cell types, states, and interactions that may limit the response to targeted immune therapy, and finally suggests stromal cells as key drivers in recurrent and locally invasive ccRCC. These and future single-cell transcriptomics studies will continue to clarify the cellular milieu in the ccRCC microenvironment, thus defining actional clinical, therapeutic, and prognostic characteristics of ccRCC.

Item ID: 76801
Item Type: Article (Research - C1)
ISSN: 2234-943X
Keywords: clear cell renal cell carcinoma, proximal tubular epithelial cells, tumor associate macrophages, CD8(+) T cells, cancer associated fibroblasts
Copyright Information: Copyright © 2022 Raghubar, Roberts, Wood, Healy, Kassianos and Mallett. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Date Deposited: 16 Nov 2022 07:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 100%
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