Lai, Xin, Schmitz, Ulf, and Vera, Julio (2022) The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective. In: Schmitz, Ulf, Wolkenhauer, Olaf, and Vera, Julio, (eds.) The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective. Advances in Experimental Medicine and Biology, 1385 . Springer, Cham, pp. 1-22.

PDF (Published Version) - Published Version Restricted to Repository staff only

Abstract

Since the discovery of microRNAs (miRNAs) in Caenorhabditis elegans, our understanding of their cellular function has progressed continuously. Today, we have a good understanding of miRNA-mediated gene regulation, miRNA-mediated cross talk between genes including competing endogenous RNAs, and miRNA-mediated signaling transduction both in normal human physiology and in diseases.

Besides, these noncoding RNAs have shown their value for clinical applications, especially in an oncological context. They can be used as reliable biomarkers for cancer diagnosis and prognosis and attract increasing attention as potential therapeutic targets. Many achievements made in the miRNA field are based on joint efforts from computational and molecular biologists. Systems biology approaches, which integrate computational and experimental methods, have played a fundamental role in uncovering the cellular functions of miRNAs.

In this chapter, we review and discuss the role of miRNAs in oncology from a system biology perspective. We first describe biological facts about miRNA genetics and function. Next, we discuss the role of miRNAs in cancer progression and review the application of miRNAs in cancer diagnostics and therapy. Finally, we elaborate on the role that miRNAs play in cancer gene regulatory networks. Taken together, we emphasize the importance of systems biology approaches in our continued efforts to study miRNA cancer regulation.

Item ID:	76788
Item Type:	Book Chapter (Research - B1)
ISBN:	978-3-031-08356-3
ISSN:	0065-2598
Copyright Information:	© The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Funders:	National Health & Medical Research Council (NHMRC)
Projects and Grants:	NHMRC Investigator Grant (#1196405)
Date Deposited:	15 Nov 2022 01:26
FoR Codes:	31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310299 Bioinformatics and computational biology not elsewhere classified @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 30% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310114 Systems biology @ 40%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 100%
Downloads:	Total: 3
	More Statistics