Percutaneous absorption in frogs: in vitro and in vivo studies. Developing models for disease treatment and environmental risk management
Llewelyn, Victoria Kathleen (2019) Percutaneous absorption in frogs: in vitro and in vivo studies. Developing models for disease treatment and environmental risk management. PhD thesis, James Cook University.
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Abstract
Tori Llewelyn investigated delivery of chemicals through the skin of frogs, with the rate and extent of absorption found to differ depending on the frog's habitat. Tori developed the first model of absorption that will both inform the design of treatments for disease in frogs, and also advise risk-management in frog habitats.
| Item ID: | 75739 |
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| Item Type: | Thesis (PhD) |
| Keywords: | Absorption, Administration, Amphibians, Anura, Chytridiomycosis, Cutaneous, Disease, Frog, Octanol-water partition coefficient, Pharmaceutical science, Skin absorption, Skin, Toxicokinetics, Toxicology, Transdermal, Treatment, Wildlife toxicology, Zoology |
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| Copyright Information: | Copyright © 2019 Victoria Kathleen Llewelyn. |
| Additional Information: | For this thesis, Victoria Llewelyn received the Dean's Award for Excellence 2020. Permanent embargo on Chapters 2-8 and Appendices 1, 2b and 5. Six publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: Chapter 2: Llewelyn, V.K., Berger, L., and Glass, B.D. (2016) Percutaneous absorption of chemicals: developing an understanding for the treatment of disease in frogs. Journal of Veterinary Pharmacology and Therapeutics, 39 (2). pp. 109-121. Chapter 3: Llewelyn, Victoria K., Berger, Lee, and Glass, Beverley D. (2018) Regional variation in percutaneous absorption in the tree frog Litoria caerulea. Environmental Toxicology and Pharmacology, 60. pp. 5-11. Chapter 3: Llewelyn, Victoria K., Berger, Lee, and Glass, Beverley D. (2019) Effects of skin region and relative lipophilicity on percutaneous absorption in the toad Rhinella marina. Environmental Toxicology and Chemistry, 38 (2). pp. 361-367. Chapter 5: Llewelyn, Victoria K., Berger, Lee, and Glass, Beverley D. (2019) Permeability of frog skin to chemicals: effect of penetration enhancers. Heliyon, 5 (8). e02127. Chapter 6: Llewelyn, Victoria K., Berger, Lee, and Glass, Beverley D. (2020) Can models of percutaneous absorption based on in vitro data in frogs predict in vivo absorption? PLoS ONE, 15 (7). e0235737. Chapter 7: Llewelyn, Victoria K., Berger, Lee, and Glass, Beverley D. (2021) Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data. BMC Veterinary Research, 17 (1). 57. |
| Date Deposited: | 16 Aug 2022 02:58 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3109 Zoology > 310907 Animal physiological ecology @ 100% |
| SEO Codes: | 18 ENVIRONMENTAL MANAGEMENT > 1806 Terrestrial systems and management > 180606 Terrestrial biodiversity @ 50% 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280102 Expanding knowledge in the biological sciences @ 50% |
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