Schultz, Julia, Koczan, Dirk, Schmitz, Ulf, Ibrahim, Saleh M., Pilch, Dominik, Landsberg, Jenny, and Kunz, Manfred (2010) Tumor-promoting role of signal transducer and activator of transcription (Stat)1 in late-stage melanoma growth. Clinical and Experimental Metastasis, 27. pp. 133-140.

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Abstract

A large-scale gene expression study of melanoma metastases was performed to identify genes involved in late-stage tumor progression. Overall 248 genes, out of more than 47,000 tested, are differentially expressed when comparing peripheral areas (invasion front) with central tumor areas of melanoma metastases. As determined by gene ontology analysis, members of the STAT signaling pathway show significant enrichment. In particular, Stat1 is highly expressed in peripheral compared with central tumor areas. In line with this, stable knockdown of STAT1 in metastatic melanoma cells significantly impairs their migratory and invasive capacity in wounding and matrigel assays. Moreover, STAT1 knockdown affects the metastatic behavior of melanoma cells in a mouse model of melanoma metastasis. Taken together, these data suggest that Stat1 might play a role in late-stage melanoma progression. Interference with the Stat1 pathway could have therapeutic implications for late-stage melanoma patients.

Item ID:	69027
Item Type:	Article (Research - C1)
ISSN:	1573-7276
Copyright Information:	© Springer Science+Business Media B.V. 2010
Date Deposited:	25 Jun 2024 03:17
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 100%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100%
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