Vera, Julio, Lai, Xin, Schmitz, Ulf, and Wolkenhauer, Olaf (2012) MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology. In: Schmitz, Ulf, Wolkenhauer, Olaf, and Vera, Julio, (eds.) MicroRNA Cancer Regulation: Advanced Concepts, Bioinformatics and Systems Biology Tools. Springer Nature, Dordrecht, Netherlands, pp. 55-76.

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Abstract

MicroRNAs (miRNAs) are involved in many regulatory pathways some of which are complex networks enriched in regulatory motifs like positive or negative feedback loops or coherent and incoherent feedforward loops. Their complexity makes the understanding of their regulation difficult and the interpretation of experimental data cumbersome. In this book chapter we claim that systems biology is the appropriate approach to investigate the regulation of these miRNA-regulated networks. Systems biology is an interdisciplinary approach by which biomedical questions on biochemical networks are addressed by integrating experiments with mathematical modelling and simulation. We here introduce the foundations of the systems biology approach, the basic theoretical and computational tools used to perform model-based analyses of miRNA-regulated networks and review the scientific literature in systems biology of miRNA regulation, with a focus on cancer.

Item ID:	69019
Item Type:	Book Chapter (Research - B1)
ISBN:	9789400755901
Copyright Information:	© 2013 Springer Science+Business Media Dordrecht.
Date Deposited:	18 Dec 2024 07:06
FoR Codes:	31 BIOLOGICAL SCIENCES > 3102 Bioinformatics and computational biology > 310201 Bioinformatic methods development @ 60% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321101 Cancer cell biology @ 40%
SEO Codes:	28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280103 Expanding knowledge in the biomedical and clinical sciences @ 100%
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