Characterisation of the proteomic composition of Schistosoma haematobium extracellular vesicles: towards the development of vaccine and diagnostic candidate antigens
Mekonnen, Gebeyaw Getnet (2019) Characterisation of the proteomic composition of Schistosoma haematobium extracellular vesicles: towards the development of vaccine and diagnostic candidate antigens. PhD thesis, James Cook University.
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Abstract
Gebeyaw Getnet Mekonnen characterised the proteomic composition of different populations of extracellular vesicles (EVs) from Schistosoma haematobium adult worms and assessed the vaccine and diagnostic efficacy of selected EV-membrane proteins. He found that S. haematobium EV tetraspanins are potential diagnostic candidates, which has resulted in a patent.
| Item ID: | 68716 |
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| Item Type: | Thesis (PhD) |
| Keywords: | Extracellular vesicles, Schistosomiasis, Tetraspanin, Vaccine, Helminths, Proteins |
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| Copyright Information: | Copyright © 2019 Gebeyaw Getnet Mekonnen. |
| Additional Information: | Two publications arising from this thesis are stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publications are: Mekonnen, Gebeyaw Getnet, Pearson, Mark, Loukas, Alex, and Sotillo, Javier (2018) Extracellular vesicles from parasitic helminths and their potential utility as vaccines. Expert Review of Vaccines, 17 (3). pp. 197-205. Mekonnen, Gebeyaw G., Tedla, Bemnet A., Pickering, Darren, Becker, Luke, Wang, Lei, Zhan, Bin, Bottazzi, Maria Elena, Loukas, Alex, Sotillo, Javier, and Pearson, Mark S. (2020) Schistosoma haematobium extracellular vesicle proteins confer protection in a heterologous model of schistosomiasis. Vaccines, 8 (3). 416. |
| Date Deposited: | 20 Jul 2021 23:31 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50% 20 HEALTH > 2004 Public health (excl. specific population health) > 200412 Preventive medicine @ 50% |
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